Document Detail


Lipoprotein(a): new insights into mechanisms of atherogenesis and thrombosis.
MedLine Citation:
PMID:  15188938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoprotein(a) (Lp[a]) continues to be a controversial molecule regarding its role in human vascular disease. Although the physiologic role of this molecule is still unclear, novel discoveries within the last few years have suggested numerous mechanisms whereby Lp(a) may contribute to atherosclerosis and its complications in human subjects. These effects may differentially occur in vascular tissue and circulating blood compartments. A complex interplay between tissue-specific effects is probably more relevant to the pathogenicity of this molecule than one single effect alone. This review briefly describes the structure of Lp(a) in relation to its biochemical function, summarizing the current literature on various pathophysiologic mechanisms of Lp(a)-induced vascular disease and the role of cell and tissue-specific effects in promoting atherogenesis and thrombosis.
Authors:
Arjun Deb; Noel M Caplice
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical cardiology     Volume:  27     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-06-10     Completed Date:  2004-10-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  258-64     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Diseases and Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Arteriosclerosis / etiology*,  metabolism,  physiopathology*
Blood Coagulation / physiology
Endothelium, Vascular / physiopathology
Humans
Lipoprotein(a) / physiology*
Thromboplastin / physiology
Thrombosis / etiology*,  metabolism,  physiopathology*
Chemical
Reg. No./Substance:
0/Lipoprotein(a); 9035-58-9/Thromboplastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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