Document Detail


Lipoprotein(a) in patients with acute cerebral ischemia.
MedLine Citation:
PMID:  8685934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: In several cross-sectional studies, a high serum lipoprotein(a) [Lp(a)] level was found to be an independent risk factor for cerebral infarction. In a recent prospective study, however, no association was found between Lp(a) levels at baseline and future risk of stroke. Whether Lp(a) is a prognostic factor in a high-risk population of patients with acute ischemic stroke remains unclear. METHODS: We assessed Lp(a) level on admission to study its relationship with cardiovascular risk profile, stroke severity, and prognosis in 151 consecutive patients with acute cerebral ischemia. The mean follow-up period was 2.5 +/- 1.2 years. Lp(a) was measured by means of a solid-phase two-site immunoradiometric assay. RESULTS: Increased Lp(a) levels were found in 53 (35%) of the patients with cerebral ischemia. Median (5th and 95th percentile) values of Lp(a) were 191 (12 and 1539) mg/L and 197 (10 and 1255) mg/L for patients with transient ischemic attack and patients with ischemic stroke, respectively. No relationship was found between Lp(a) levels and stroke severity (P=.68) or the occurrence of vascular events during follow-up (P log rank=0.81). CONCLUSIONS: We conclude that Lp(a) is increased in about one third of patients with acute cerebral ischemia, but it does not appear to be associated with the cardiovascular risk profile, stroke characteristics, or the prognosis of such patients.
Authors:
F van Kooten; J van Krimpen; D W Dippel; N Hoogerbrugge; P J Koudstaal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  27     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-22     Completed Date:  1996-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1231-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Hospital Rotterdam Dijkzigt, the Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Atrial Fibrillation / blood
Brain Ischemia / blood*
Cerebral Hemorrhage / blood
Cerebral Infarction / blood
Cerebrovascular Disorders / blood
Female
Follow-Up Studies
Heart Diseases / blood
Humans
Immunoradiometric Assay
Ischemic Attack, Transient / blood
Lipoprotein(a) / blood*
Male
Myocardial Infarction / blood
Prognosis
Risk Factors
Survival Analysis
Survival Rate
Chemical
Reg. No./Substance:
0/Lipoprotein(a)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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