Document Detail


Lipoprotein(a) in diet-induced atherosclerosis in nonhuman primates.
MedLine Citation:
PMID:  1824815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoprotein(a) (Lp[a]) is a low density lipoprotein particle that contains plasminogen-like apolipoprotein(a). Recent studies suggest an association of Lp(a) with atherosclerotic vascular disease. We have studied the accumulation of Lp(a) in atherosclerotic arteries of monkeys with diet-induced atherosclerosis. Immunohistochemistry with monospecific Lp(a) antisera revealed striking accumulations of Lp(a) in atherosclerotic coronary artery lesions. There was no Lp(a) in the normal, nonatherosclerotic arteries. Analysis of paired tissue and serum samples from 17 male hyperlipoproteinemic monkeys revealed a significant correlation between aortic wall Lp(a) and serum Lp(a) levels. The serum cholesterol level failed to correlate with either aortic Lp(a) or serum Lp(a). These results add further evidence for the potential role of Lp(a) in the pathogenesis of atherosclerosis.
Authors:
R L Nachman; D Gavish; N Azrolan; T B Clarkson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association     Volume:  11     ISSN:  1049-8834     ISO Abbreviation:  Arterioscler. Thromb.     Publication Date:    1991 Jan-Feb
Date Detail:
Created Date:  1991-02-27     Completed Date:  1991-02-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9101388     Medline TA:  Arterioscler Thromb     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  32-8     Citation Subset:  IM    
Affiliation:
Division of Hematology-Oncology, Cornell University Medical College, New York, NY 10021.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / chemistry
Apolipoproteins B / analysis
Arteriosclerosis / etiology,  metabolism*
Coronary Vessels / chemistry
Diet, Atherogenic
Fibrinogen / analysis
Fibronectins / analysis
Immunohistochemistry
Lipoprotein(a)
Lipoproteins / analysis*
Macaca fascicularis
Macaca mulatta
Male
Grant Support
ID/Acronym/Agency:
HL-18828/HL/NHLBI NIH HHS; HL-32935/HL/NHLBI NIH HHS; HL-36961/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins B; 0/Fibronectins; 0/Lipoprotein(a); 0/Lipoproteins; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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