Document Detail


Lipoprotein(a): importance for the fibrinolytic system and thromboembolic complications
MedLine Citation:
PMID:  16738838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoprotein(a) has been pre-occupying cardiovascular scientists since 1963. The pathogenic significance of the lipoprotein(a) molecule (Figure 1) with regard to the development of arteriosclerosis and coronary heart disease gained increasing recognition during the 1970s, as has its negative influence on the endothelial fibrinolytic system over the past 15 years. Although the importance of lipoprotein(a) for the fibrinolytic system has not been adequately assessed hitherto in the majority of cardiologic studies, it is, in fact, precisely this negative influence, that constitutes the actual risk for thrombotic complications in the cardiovascular system as a whole. However, the true risk factor seems to be a low isoform of apo(a). These patient groups, who can nowadays be accurately defined by means of molecular biological studies, may possibly constitute an at-risk population that can be protected from further thrombotic complications. This article sets out to examine the copious evidence for further proatherogenic and prothrombotic properties of lipoprotein(a) (Figure 2) and discuss the molecular and pathophysiological mechanisms in the critical stage in early atherogenesis and thrombosis.
Authors:
Roman Leischik; Birgit Dworrak
Publication Detail:
Type:  Comparative Study; English Abstract; Journal Article; Review    
Journal Detail:
Title:  Herz     Volume:  31     ISSN:  0340-9937     ISO Abbreviation:  Herz     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-06-01     Completed Date:  2006-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  144-52     Citation Subset:  IM    
Affiliation:
Kardiologische Praxis Dr. med. Roman Leischik, Mittelstrasse 13, 58095 Hagen. literatur@dr-leischik.de
Vernacular Title:
Lipoprotein(a): Bedeutung für das fibrinolytische System und thromboembolische Komplikationen.
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoproteins A / genetics
Arteriosclerosis / blood,  etiology*
Child
Coronary Disease / blood
Fibrinolysis* / physiology
Humans
Lipoprotein(a) / blood*,  physiology*
Protein Isoforms
Risk Factors
Thromboembolism / blood*,  etiology
Thrombosis / blood,  etiology*
Chemical
Reg. No./Substance:
0/Apolipoproteins A; 0/Lipoprotein(a); 0/Protein Isoforms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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