| Lipoprotein(a) concentration does not differ between sexes in healthy offspring of patients with premature myocardial infarction. | |
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MedLine Citation:
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PMID: 21519277 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Although a family history of coronary artery disease (CAD) is an established factor influencing lipoprotein(a) [Lp(a)] levels, the effect of sex on Lp(a) concentration remains unclear. A potential cause of the conflicting findings regarding the effect of sex on this novel CAD risk factor is the limited ability of the studies, to date, to adequately control for the potential confounding effect of CAD familial predisposition. Our purpose was to evaluate the influence of sex on Lp(a) concentration in healthy young individuals by controlling for family history of CAD. In order to achieve our goal, we compared Lp(a) levels in pairs of brothers and sisters with a positive parental history of premature myocardial infarction (PHPMI). METHODS: We measured Lp(a) concentration in 77 healthy brother-sister pairs with PHPMI (mean age: brothers: 18.4 ± 6.2 years and sisters: 18.1 ± 5.8 years). Total cholesterol, low-density lipoprotein (LDL)-cholesterol and high-density lipoprotein (HDL)-cholesterol, triglycerides, apolipoprotein (Apo) A-I and B were also measured. RESULTS: Lp(a) levels did not differ between siblings of different sex (male vs. female sex: 0.994 ± 1.29 vs. 0.860 ± 0.82 μmol/l, P = 0.940); moreover, the prevalence of elevated (>1.071 μmol/l) Lp(a) concentrations between sexes was the same (29.9%). As expected, compared to female sex, male sex showed higher total/HDL-cholesterol ratio (3.642 ± 0.99 vs. 3.329 ± 0.89, P = 0.017) and lower HDL-cholesterol (1.221 ± 0.24 vs. 1.343 ± 0.28 mmol/l, P = 0.001), Apo A-I (1.390 ± 0.20 vs. 1.474 ± 0.23 g/l, P = 0.003) concentrations and Apo A-I/Apo B ratio (1.632 ± 0.49 vs. 1.830 ± 0.66, P = 0.016). CONCLUSION: Our results show that healthy young men with PHPMI have a similar Lp(a) levels but worse lipid profile than women. |
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Authors:
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Silvia Barra; Vittoria Cuomo; Nunzia Silvestri; Crescenzo Materazzi; Giancarlo Vitagliano; Giovanbattista Capozzi; Silvio Caruso; Giovanni Gaeta; Maurizio Trevisan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-23 |
Journal Detail:
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Title: Journal of cardiovascular medicine (Hagerstown, Md.) Volume: - ISSN: 1558-2035 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101259752 Medline TA: J Cardiovasc Med (Hagerstown) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aCardiology Unit, Antonio Cardarelli Hospital, Naples, Italy bCardiology Unit, Second University of Naples, Monaldi Hospital, Italy cClinical Analysis Laboratory, A. Cardarelli Hospital, Naples, Italy dHealth Sciences System of the Nevada System of Higher Education, Las Vegas, Nevada, USA. |
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