| Lipoprotein(a) as a risk factor for maternal cardiovascular disease mortality in kindreds with familial combined hyperlipidemia or familial hypertriglyceridemia. | |
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MedLine Citation:
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PMID: 11595020 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most but not all epidemiologic studies have shown that lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease (CVD). Lp(a) levels are also strongly genetically influenced. The purpose of this study was to evaluate the association between Lp(a) levels in adult offspring and parental CVD mortality in 61 kindreds with familial forms of hyperlipidemia. The study sample consisted of offspring-parent pairs in which offspring had fasting Lp(a) measurements and parents had 20-year vital status data and standardized cause-of-death classification if deceased. Linear regression analyses, using a robust variance estimator, were performed separately for 241 offspring with known maternal history (114 mothers) and 194 offspring with known paternal history (93 fathers). Maternal history of CVD mortality was significantly (p=0.004) associated with 2.4-fold higher median Lp(a) levels in offspring compared with those with no maternal history, independent of diabetes, lipid-lowering medications and hormone use. No association was observed between paternal CVD mortality and offspring Lp(a) levels (p=0.505). Adjusting for apolipoprotein(a) kringle 4 number did not alter these parent-specific associations. In conclusion, Lp(a) levels in offspring may be associated with maternal but not paternal history of CVD mortality. This parent-specific finding needs to be confirmed in other samples of high-risk families. |
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Authors:
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H Kim; S M Marcovina; K L Edwards; B McKnight; C M Bradley; M J McNeely; B M Psaty; A G Motulsky; M A Austin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical genetics Volume: 60 ISSN: 0009-9163 ISO Abbreviation: Clin. Genet. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-10-11 Completed Date: 2002-01-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0253664 Medline TA: Clin Genet Country: Denmark |
Other Details:
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Languages: eng Pagination: 188-97 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cardiovascular Diseases / diagnosis*, etiology*, mortality Cholesterol / metabolism Dose-Response Relationship, Drug Family Health Fathers Female Follow-Up Studies Humans Hyperlipidemia, Familial Combined / diagnosis*, genetics*, mortality Hypertriglyceridemia / diagnosis*, genetics* Kringles Linear Models Lipoprotein(a) / biosynthesis*, chemistry*, genetics* Male Middle Aged Mothers Pedigree Polymorphism, Genetic Risk Factors Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL-30086/HL/NHLBI NIH HHS; HL-49513/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipoprotein(a); 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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