Document Detail

Lipoprotein(a) and SYNTAX Score Association with Severity of Coronary Artery Atherosclerosis in North India.
MedLine Citation:
PMID:  23275843     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVES: This cross-sectional study investigated the association of lipoprotein(a) [Lp(a)] levels as an atherosclerosis predictor and their relationship to the severity of coronary artery disease (CAD).
METHODS: 360 consecutive patients at Sanjay Gandhi Postgraduate Institute of Medical Sciences and King George's Medical University hospitals, Lucknow, North India, with chest pains, CAD symptoms and on lipid-lowering therapy were enrolled between June 2009 and October 2011. Before coronary artery angiography (CAG), a fasting blood sample was assessed for lipid and Lp(a) levels. The synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score was calculated according to the CAG results. Patients were divided into 3 groups based on CAD severity and SYNTAX scores.
RESULTS: Angiography revealed CAD in 270 patients. Lp(a) levels were higher in CAD compared to non-CAD patients (48.7 ± 23.8 mg/dl versus 18.9 ± 11.1 mg/dl [P <0.0001]). The levels of Lp(a) were lower in single than in double and triple vessels (39.3 ± 18.4 mg/dl versus 58.0 ± 23.0 mg/dl, and 69.2 ± 24.1 mg/dl, [P <0.05]). Lp(a) levels were significantly higher in severe CAD with SYNTAX score >30 (88.0±24.0 mg/dl). Lp(a) levels correlated significantly with SYNTAX scores (r = 0.70, P <0.0001).
CONCLUSION: In this study, Lp(a) levels were positively associated with a patient's SYNTAX score in diseased vessels. Furthermore, an elevated Lp(a) level was a causal, independent risk factor of CAD. Lowering Lp(a) levels would reduce CAD in primary and secondary prevention settings. There is an urgent need to define more precisely which patients to treat and which to target for earlier interventions.
Fauzia Ashfaq; P K Goel; Nagraja Moorthy; Rishi Sethi; Mohammed Idrees Khan; Mohammed Zafar Idris
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Publication Detail:
Type:  Journal Article     Date:  2012-11-20
Journal Detail:
Title:  Sultan Qaboos University medical journal     Volume:  12     ISSN:  2075-051X     ISO Abbreviation:  Sultan Qaboos Univ Med J     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-01-01     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101519915     Medline TA:  Sultan Qaboos Univ Med J     Country:  Oman    
Other Details:
Languages:  eng     Pagination:  465-72     Citation Subset:  -    
Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;
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