| Lipoprotein(a), Interleukin-10, C-Reactive Protein, and 8-Year Outcome After Percutaneous Coronary Intervention. | |
| | |
MedLine Citation:
|
PMID: 22488248 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: This prospective study investigated the association between preprocedural biomarker levels and incident major adverse cardiac events (MACE) in complex patients undergoing percutaneous coronary intervention (PCI) with sirolimus-eluting stenting. HYPOTHESIS: Lipoprotein(a) (Lp[a]), interleukin-10 (IL-10), and high-sensitivity C-reactive protein (CRP) have long-term prognostic value in patients undergoing PCI. METHODS: Between April 2002 and February 2003, 161 patients were included in the study. Blood was drawn before the procedure, and biomarkers were measured. Patients were followed-up for MACE (death, nonfatal myocardial infarction, and repeat revascularization). Cox proportional hazard models were used to determine risk of MACE for tertiles of biomarkers. Both 1-year and long-term follow-up (median, 6 years; maximum, 8 years) were evaluated. RESULTS: Mean age was 59 years, and 68% were men. During long-term follow-up, 72 MACE occurred (overall crude cumulative incidence: 45% [95% confidence interval (CI): 37%-52%]). Lp(a) was associated with a higher 1-year risk of MACE, with an adjusted hazard ratio (HR) of 3.1 (95% CI: 1.1-8.6) for the highest vs the lowest tertile. This association weakened and lost significance with long-term follow-up. IL-10 showed a tendency toward an association with MACE. The 1-year HR was 2.1 (95% CI: 0.92-5.0). Long-term follow-up rendered a similar result. The association of CRP with MACE did not reach statistical significance at 1-year follow-up. However, CRP was associated with long-term risk of MACE, with an HR of 1.9 (95% CI: 1.0-3.5). CONCLUSIONS: In this prospective study, preprocedural Lp(a) level was associated with short-term prognosis after PCI. The preprocedural CRP level was associated with long-term prognosis after PCI. Clin. Cardiol. 2012 DOI: 10.1002/clc.21988 The authors have no funding, financial relationships, or conflicts of interest to disclose. |
| | |
Authors:
|
Isabella Kardys; Rohit M Oemrawsingh; I Patrick Kay; Gregory T Jones; Sally P A McCormick; Joost Daemen; Robert Jan Van Geuns; Eric Boersma; Ron T Van Domburg; Patrick W Serruys |
Related Documents
:
|
12507128 - Endovascular reconstruction of intracranial arteries by stent placement and combined te... 23508318 - First year prognosis of patients hospitalized in an acute geriatric ward with a known d... 17495218 - Prognosis and safety of anticoagulation in intracranial artery dissections in adults. 2907108 - Long-term outcome of the management of ruptured intracranial aneurysm. review of 328 co... 3114038 - Impact of endoscopy on mortality from occult cancer in radiographically benign gastric ... 16278638 - Is carotid endarterectomy in octogenarians more dangerous than in younger patients? |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-9 |
Journal Detail:
|
Title: Clinical cardiology Volume: - ISSN: 1932-8737 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 Wiley Periodicals, Inc. |
Affiliation:
|
Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands. i.kardys@erasmusmc.nl. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member...
Next Document: Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy o...