Document Detail

Lipoprotein(a), inflammation, and peripheral arterial disease in a community-based sample of older men and women (the InCHIANTI study).
MedLine Citation:
PMID:  20538138     Owner:  NLM     Status:  MEDLINE    
Lipoprotein(a) (Lp[a]) may represent an independent risk factor for peripheral arterial disease of the lower limbs (LL-PAD), but prospective data are scant. We estimated the association between baseline Lp(a) with prevalent and incident LL-PAD in older subjects from the InCHIANTI Study. LL-PAD, defined as an ankle-brachial index <0.90, was assessed at baseline and over a 6-year follow-up in a sample of 1,002 Italian subjects 60 to 96 years of age. Plasma Lp(a) and potential traditional and novel cardiovascular risk factors (including a score based on relevant inflammatory markers) were entered in multivariable models to assess their association with prevalent and incident LL-PAD. At baseline, Lp(a) concentration was directly related to the number of increased inflammatory markers (p <0.05). There were 125 (12.5%) prevalent cases of LL-PAD and 57 (8.3%) incident cases. After adjustment for potential confounders, participants in the highest quartile of the Lp(a) distribution (>/=32.9 mg/dl) were more likely to have LL-PAD compared to those in the lowest quartile (odds ratio [OR] 1.83, 95% confidence interval [CI] 1.01 to 3.33). The association was stronger (OR 3.80, 95% CI 1.50 to 9.61) if LL-PAD was defined by harder criteria, namely an ankle-brachial index <0.70. Compared to subjects in the lowest Lp(a) quartile, those in the highest quartile showed a somewhat increased risk of incident LL-PAD (lowest quartile 7.7%, highest quartile 10.8%), but the association was not statistically significant (OR 1.52, 95% CI 0.71 to 3.22). In conclusion, Lp(a) is an independent LL-PAD correlate in the cross-sectional evaluation, but further prospective studies in larger populations, with longer follow-up and more definite LL-PAD ranking, might be needed to establish a longitudinal association.
Stefano Volpato; Giovanni B Vigna; Mary M McDermott; Margherita Cavalieri; Cinzia Maraldi; Fulvio Lauretani; Stefania Bandinelli; Giovanni Zuliani; Jack M Guralnik; Renato Fellin; Luigi Ferrucci
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2010-04-27
Journal Detail:
Title:  The American journal of cardiology     Volume:  105     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-07-06     Revised Date:  2011-08-01    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1825-30     Citation Subset:  AIM; IM    
Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy.
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MeSH Terms
Age Distribution
Age Factors
Aged, 80 and over
Biological Markers / blood
Blood Pressure
Brachial Artery / physiopathology,  ultrasonography
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Inflammation / blood*,  epidemiology
Italy / epidemiology
Lipoprotein(a) / blood*
Middle Aged
Peripheral Vascular Diseases / blood*,  epidemiology,  physiopathology
Prospective Studies
Severity of Illness Index
Sex Distribution
Tibial Arteries / physiopathology,  ultrasonography
Time Factors
Ultrasonography, Doppler
Urban Population*
Grant Support
263 MD821336/MD/NCMHD NIH HHS; 263 MD9164 13/MD/NCMHD NIH HHS; N.1-AG-1-1/AG/NIA NIH HHS; N.1-AG-1-2111/AG/NIA NIH HHS; N01 AG5-002/AG/NIA NIH HHS; N01-AG-5-0002/AG/NIA NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Lipoprotein(a)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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