| Lipoprotein-specific transport of circulating lipid peroxides. | |
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MedLine Citation:
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PMID: 20718696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Serum lipoproteins, the carriers of cholesterol and other lipophilic substances in blood, are known to contain variable amounts of lipid peroxides. We investigated the transport of food-derived and endogenously formed lipid peroxides by serum lipoproteins under physiological conditions. METHODS: Five independent trials were conducted in which different groups of healthy volunteers either consumed a test meal (a standard hamburger meal rich in lipid peroxides) or underwent strenuous physical exercise. The transport function was characterized by analyzing the kinetics of lipid peroxides in lipoprotein fractions. For evaluation of their potential involvement, indicators of oxidative stress (8-isoprostanes, malondialdehyde, 8-oxo-deoxyguanosine), antioxidant functions (total antioxidant potential, paraoxonase activity), and serum lipids were also analyzed. RESULTS: We found that food lipid peroxides are incorporated into serum triglyceride-rich lipoproteins and low-density lipoprotein, directing the flow of lipid peroxides towards peripheral tissues. High-density lipoprotein appears to have an opposite and protective function, and is able to respond to oxidative stress by substantially increasing the reverse transport of lipid peroxides. CONCLUSIONS: We propose that the specific atherosclerosis-related effects of serum lipoproteins are not explained by cholesterol transport alone and may rather result from the transport of the more directly atherogenic lipid peroxides. |
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Authors:
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Markku Ahotupa; Jukka-Pekka Suomela; Timo Vuorimaa; Tommi Vasankari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of medicine Volume: 42 ISSN: 1365-2060 ISO Abbreviation: Ann. Med. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8906388 Medline TA: Ann Med Country: England |
Other Details:
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Languages: eng Pagination: 521-9 Citation Subset: IM |
Affiliation:
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MCA Research Laboratory, Department of Physiology, University of Turku, Turku, Finland. markku.ahotupa@utu.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Transport Deoxyguanosine / analogs & derivatives, metabolism Dietary Fats / metabolism* Dinoprost / analogs & derivatives, blood Exercise / physiology Female Food Humans Lipid Metabolism / physiology* Lipid Peroxides / blood*, pharmacokinetics* Lipoproteins, HDL / blood*, physiology Lipoproteins, LDL / blood*, physiology Male Malondialdehyde / blood Middle Aged Oxidative Stress* Postprandial Period / physiology Triglycerides / blood*, physiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Lipid Peroxides; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Triglycerides; 27415-26-5/8-epi-prostaglandin F2alpha; 542-78-9/Malondialdehyde; 551-11-1/Dinoprost; 88847-89-6/8-oxo-7-hydrodeoxyguanosine; 961-07-9/Deoxyguanosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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