Document Detail


Lipoprotein secretion and triglyceride stores in the heart.
MedLine Citation:
PMID:  11481337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in mouse and human heart tissue. Why the heart would express these "lipoprotein assembly" genes has been unclear. Here we demonstrate that the beating mouse heart actually secretes spherical lipoproteins. Moreover, increased cardiac production of lipoproteins (e.g., in mice that express a human apolipoprotein B transgene) was associated with increased triglyceride secretion from the heart and decreased stores of triglycerides within the heart. Increased cardiac production of lipoproteins also reduced the pathological accumulation of triglycerides that occurs in the hearts of mice lacking long-chain acyl coenzyme A dehydrogenase. In contrast, blocking heart lipoprotein secretion (e.g., in heart-specific microsomal triglyceride transfer protein knockout mice) increased cardiac triglyceride stores. Thus, heart lipoprotein secretion helps regulate cardiac triglyceride stores and may protect the heart from the detrimental effects of surplus lipids.
Authors:
J Bjorkegren; M Véniant; S K Kim; S K Withycombe; P A Wood; M K Hellerstein; R A Neese; S G Young
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2001-07-31
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  276     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-15     Completed Date:  2001-12-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38511-7     Citation Subset:  IM    
Affiliation:
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141-9100, USA. jbjorkegren@gladstone.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism
Blotting, Southern
Cells, Cultured
Humans
Lipids / blood
Lipoproteins / secretion*
Liver / metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Microscopy, Electron
Myocardium / metabolism*,  ultrastructure
Perfusion
Reverse Transcriptase Polymerase Chain Reaction
Time Factors
Triglycerides / biosynthesis*,  metabolism
Grant Support
ID/Acronym/Agency:
HL-41633/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Lipids; 0/Lipoproteins; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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