| Lipoprotein secretion and triglyceride stores in the heart. | |
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MedLine Citation:
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PMID: 11481337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in mouse and human heart tissue. Why the heart would express these "lipoprotein assembly" genes has been unclear. Here we demonstrate that the beating mouse heart actually secretes spherical lipoproteins. Moreover, increased cardiac production of lipoproteins (e.g., in mice that express a human apolipoprotein B transgene) was associated with increased triglyceride secretion from the heart and decreased stores of triglycerides within the heart. Increased cardiac production of lipoproteins also reduced the pathological accumulation of triglycerides that occurs in the hearts of mice lacking long-chain acyl coenzyme A dehydrogenase. In contrast, blocking heart lipoprotein secretion (e.g., in heart-specific microsomal triglyceride transfer protein knockout mice) increased cardiac triglyceride stores. Thus, heart lipoprotein secretion helps regulate cardiac triglyceride stores and may protect the heart from the detrimental effects of surplus lipids. |
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Authors:
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J Bjorkegren; M Véniant; S K Kim; S K Withycombe; P A Wood; M K Hellerstein; R A Neese; S G Young |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2001-07-31 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 276 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-15 Completed Date: 2001-12-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 38511-7 Citation Subset: IM |
Affiliation:
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Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141-9100, USA. jbjorkegren@gladstone.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Blotting, Southern Cells, Cultured Humans Lipids / blood Lipoproteins / secretion* Liver / metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microscopy, Electron Myocardium / metabolism*, ultrastructure Perfusion Reverse Transcriptase Polymerase Chain Reaction Time Factors Triglycerides / biosynthesis*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL-41633/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Lipids; 0/Lipoproteins; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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