| Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. | |
| | |
MedLine Citation:
|
PMID: 19774217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Low-density lipoprotein (LDL) cholesterol concentration has been the prime index of cardiovascular disease risk and the main target for therapy. However, several lipoprotein ratios or "atherogenic indices" have been defined in an attempt to optimize the predictive capacity of the lipid profile. In this review, we summarize their pathophysiological aspects, and highlight the rationale for using these lipoprotein ratios as cardiovascular risk factors in clinical practice, specifying their cut-off risk levels and a target for lipid-lowering therapy. Total/high-density lipoprotein (HDL) cholesterol and LDL/HDL cholesterol ratios are risk indicators with greater predictive value than isolated parameters used independently, particularly LDL. Future recommendations regarding the diagnosis and treatment of dyslipidemia, including instruments for calculating cardiovascular risk or action guidelines, should include the lipoprotein ratios with greater predictive power which, in view of the evidence-based results, are none other than those which include HDL cholesterol. |
| | |
Authors:
|
Jes?s Mill?n; Xavier Pint?; Anna Mu?oz; Manuel Z??iga; Joan Rubi?s-Prat; Luis Felipe Pallardo; Luis Masana; Alipio Mangas; Antonio Hern?ndez-Mijares; Pedro Gonz?lez-Santos; Juan F Ascaso; Juan Pedro-Botet |
Related Documents
:
|
15657157 - A randomized trial of a strategy for increasing high-density lipoprotein cholesterol le... 21073127 - Glycogen storage disease type iii with hypoketosis. 19865527 - Sage tea drinking improves lipid profile and antioxidant defences in humans. 8677757 - Prognostic relevance of lipoprotein cholesterol levels in acute lymphocytic and nonlymp... 6417447 - Plasma lipoproteins and lipolytic enzyme activities during endurance training in sedent... 6731337 - The effect of dietary consistency on gross and histologic morphology in the craniofacia... |
Publication Detail:
|
Type: Journal Article; Review Date: 2009-09-18 |
Journal Detail:
|
Title: Vascular health and risk management Volume: 5 ISSN: 1178-2048 ISO Abbreviation: Vasc Health Risk Manag Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-09-23 Completed Date: 2009-12-01 Revised Date: 2010-03-09 |
Medline Journal Info:
|
Nlm Unique ID: 101273479 Medline TA: Vasc Health Risk Manag Country: New Zealand |
Other Details:
|
Languages: eng Pagination: 757-65 Citation Subset: IM |
Affiliation:
|
Hospital Universitario Gregorio Mara??n, Madrid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antilipemic Agents
/
therapeutic use* Apolipoprotein A-I / blood Apolipoproteins B / blood Biological Markers / blood Cardiovascular Diseases / blood, etiology, prevention & control* Cholesterol, HDL / blood Cholesterol, LDL / blood Dyslipidemias / blood, complications, diagnosis, drug therapy* Evidence-Based Medicine Female Humans Lipoproteins / blood* Male Practice Guidelines as Topic Predictive Value of Tests Risk Assessment Risk Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/APOA1 protein, human; 0/Antilipemic Agents; 0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins; 0/Triglycerides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HbA1c is associated with severity of obstructive sleep apnea hypopnea syndrome in nondiabetic men.
Next Document: Antiatherogenic effects of vitamin E: the search for the Holy Grail.