Document Detail

Lipoprotein oxidation in dyslipidemia: insights into general mechanisms affecting lipoprotein oxidative behavior.
MedLine Citation:
PMID:  7670748     Owner:  NLM     Status:  MEDLINE    
Atherosclerosis susceptibility associated with elevations in specific populations of apolipoprotein-B-containing particles may involve increased oxidation of lipoproteins and associated changes in their biological properties. Lipoprotein oxidation may be potentiated by the greater mass of oxidizable lipoprotein substrates, as well as by a greater intrinsic susceptibility of the specific forms of lipoproteins that arise in these disorders. The atherogenic consequences of increased lipoprotein oxidation may be further enhanced by a greater relative potency or toxicity of the oxidized products of these lipoprotein subpopulations. This review addresses these facets of lipoprotein oxidation in several forms of dyslipidemia, and in view of both differences between and commonalities among these disorders, proposes that lipoprotein oxidative behavior is determined by a complex array of physical, chemical, and metabolic factors.
D L Tribble
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current opinion in lipidology     Volume:  6     ISSN:  0957-9672     ISO Abbreviation:  Curr. Opin. Lipidol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-10-19     Completed Date:  1995-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9010000     Medline TA:  Curr Opin Lipidol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  196-208     Citation Subset:  IM    
Department of Molecular and Nuclear Medicine, Lawrence Berkeley Laboratory, University of California, Berkeley, USA.
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MeSH Terms
Apolipoproteins B / blood,  chemistry
Fatty Acids, Unsaturated / blood
Hydrogen Peroxide
Hyperlipidemias / blood*
Lipid Peroxidation*
Lipoproteins / blood*
Reg. No./Substance:
0/Apolipoproteins B; 0/Fatty Acids, Unsaturated; 0/Lipoproteins; 7722-84-1/Hydrogen Peroxide

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