| Lipoprotein oxidation in dyslipidemia: insights into general mechanisms affecting lipoprotein oxidative behavior. | |
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MedLine Citation:
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PMID: 7670748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerosis susceptibility associated with elevations in specific populations of apolipoprotein-B-containing particles may involve increased oxidation of lipoproteins and associated changes in their biological properties. Lipoprotein oxidation may be potentiated by the greater mass of oxidizable lipoprotein substrates, as well as by a greater intrinsic susceptibility of the specific forms of lipoproteins that arise in these disorders. The atherogenic consequences of increased lipoprotein oxidation may be further enhanced by a greater relative potency or toxicity of the oxidized products of these lipoprotein subpopulations. This review addresses these facets of lipoprotein oxidation in several forms of dyslipidemia, and in view of both differences between and commonalities among these disorders, proposes that lipoprotein oxidative behavior is determined by a complex array of physical, chemical, and metabolic factors. |
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Authors:
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D L Tribble |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Current opinion in lipidology Volume: 6 ISSN: 0957-9672 ISO Abbreviation: Curr. Opin. Lipidol. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-10-19 Completed Date: 1995-10-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9010000 Medline TA: Curr Opin Lipidol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 196-208 Citation Subset: IM |
Affiliation:
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Department of Molecular and Nuclear Medicine, Lawrence Berkeley Laboratory, University of California, Berkeley, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoproteins B
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blood,
chemistry Fatty Acids, Unsaturated / blood Humans Hydrogen Peroxide Hyperlipidemias / blood* Lipid Peroxidation* Lipoproteins / blood* Oxidation-Reduction |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins B; 0/Fatty Acids, Unsaturated; 0/Lipoproteins; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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