Document Detail

Lipoprotein metabolism in normolipidemic obese women during very low calorie diet: changes in high density lipoprotein.
MedLine Citation:
PMID:  1820446     Owner:  NLM     Status:  MEDLINE    
We examined changes in high density lipoprotein (HDL) metabolism during a very low calorie diet weight reduction program in 6 massively obese normolipidemic women. The diet protocol consisted of a 1st low calorie diet (LCD; 1440, 1280, and 880 kcal daily for 1 week, each, in succession), a 1st very low calorie diet (VLCD; 420 kcal daily for 4 weeks, using Optifast 70), intermission (880 kcal daily for 1 week), the 2nd VLCD (4 weeks) and the 2nd LCD (880 and 1280-1440 kcal daily for 1 week, each). Mean body weight reduction was 18.9 kg. HDL-cholesterol, more specifically HDL2-cholesterol, reduced transiently during the 1st VLCD, intermission, and 2nd VLCD periods, and tended to increase in the 2nd LCD. Apolipoprotein (apo) A-I showed a similar change to HDL-cholesterol. However, apo A-II decreased persistently throughout the weight reduction program, and the apo A-I/apo A-II ratio increased significantly in the later part of the program. Serum triglyceride, apo B, and lipoprotein lipase (LPL) activity in post-heparin plasma did not change. These data suggest that the observed decrease in HDL-cholesterol was not due to a reduction in very low density lipoprotein-derived HDL production or to an LPL deficiency, but was consistent with reduction in chylomicron-derived HDL formation following dietary fat restriction.
T Shoji; Y Nishizawa; H Koyama; S Hagiwara; H Aratani; K Izumotani-Sasao; H Kishimoto; H Tanishita; H Morii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  37 Suppl     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-08-03     Completed Date:  1992-08-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  S57-64     Citation Subset:  IM    
Second Department of Internal Medicine, Osaka City University Medical School, Japan.
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MeSH Terms
Apolipoproteins / blood
Body Weight
Diet, Reducing*
Energy Intake
Lipids / blood
Lipoproteins, HDL / blood*
Middle Aged
Obesity / diet therapy,  metabolism*
Reg. No./Substance:
0/Apolipoproteins; 0/Lipids; 0/Lipoproteins, HDL

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