Document Detail

Lipoprotein (a) and lipid and non-lipid risk factors in coronaries risk assessment.
MedLine Citation:
PMID:  19284085     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Several studies showed that elevated plasma levels of lipoprotein(a) [Lp(a)] represent a predictor for cardiovascular risk. Based on already existing literature data, we aim to study the relationship between Lp(a), lipids and other cardiovascular risk factors in individuals with or without coronary heart disease. METHODS: We performed a cross-sectional transversal study on 208 patients (100 men and 108 women) aged between 37-75, with or without old myocardial infarction. In all the patients were evaluated the cardiovascular risk factors, the plasma level of the lipid fractions and Lp(a). The relationship between Lp(a) and the lipid and non-lipid risk factors were evaluated by the logistic regression method. RESULTS: The myocardial infarction group had higher values of plasma levels of Lp(a) (0.37 +/- 0.28 vs. 0.29 +/- 0.23 g/L, p < 0.05), and LDL-C (125.66 +/- 41.21 vs. 113.44 +/- 46.64 mg/dL, p < 0.05), than the group without coronary heart disease, as well as higher values of plasmatic TC/HDL-C ratio (4.31 +/- 1.55 vs. 4.08 +/- 1.29, p < 0.05), with significantly decreased plasmatic levels of HDL-C (45.88 +/- 12.04 vs. 53.22 +/- 23.12 mg/dL, p < 0.05). The association between the high Lp(a) plasma levels and the severity of coronary vessels number involved was significant. Multivariate analysis performed with adjustments for cardiovascular risk factors showed that the Lp(a), LDL-C and CT/HDL-C ratio levels are significant and independent predictive markers of coronary heart disease. CONCLUSION: The results show that the high Lp(a) plasma levels represent an independent cardiovascular risk factor, with superior risk prediction than the conventional lipid fractions. Our results confirm the Lp(a) as a marker for cardiovascular risk assessment in clinical practice.
Lucia Agoşton-Coldea; L D Rusu; D Zdrenghea; M L Rusu; Dana Pop; Alexandra Crăciun; Laura Poanta; M Gatfossé; Sophie Rosenstingl; Teodora Mocan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of internal medicine = Revue roumaine de médecine interne     Volume:  46     ISSN:  1220-4749     ISO Abbreviation:  Rom J Intern Med     Publication Date:  2008  
Date Detail:
Created Date:  2009-03-16     Completed Date:  2009-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304507     Medline TA:  Rom J Intern Med     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  IM    
Department of Medical Sciences, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
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MeSH Terms
Case-Control Studies
Cross-Sectional Studies
Diabetes Complications / complications
Hypertension / complications
Lipoprotein(a) / blood*
Middle Aged
Myocardial Infarction / blood*,  diagnosis,  etiology*
Obesity / complications
Risk Factors
Smoking / adverse effects
Reg. No./Substance:

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