Document Detail


Lipoprotein lipase hydrolyzes endogenous triacylglycerols in muscle of exercised rats.
MedLine Citation:
PMID:  7085407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A strenuous program of treadmill running increased endogenous lipoprotein lipase (LPL) activity 2.7-fold in the soleus and 2.8-fold in fast-red fibers of the quadriceps. Under these conditions, intracellular triacylglycerols (TG) decreased 25% in the soleus and 44% in fast-red muscle fibers. Free fatty acids (FFA) increased 2.1-fold (soleus) and 2.7-fold (fast-red). In the heart, a 2-h bout of swimming in untrained rats increased intracellular LPL activity 64% measured 24 h after work. The magnitude of the increase in endogenous LPL activity in heart was dependent on the intensity of the exercise. With elevated levels of intracellular LPL activity in the myocardium, TG was reduced 49% and FFA increased 3.4-fold. These results provide evidence that exercise may result in an increased capacity to hydrolyze intramuscular TG. Further, they suggest that LPL may be the enzyme responsible for intracellular TG hydrolysis in heart and skeletal muscle.
Authors:
L B Oscai; R A Caruso; A C Wergeles
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  52     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1059-63     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Hindlimb
Hydrolysis
Lipoprotein Lipase / metabolism*
Male
Muscles / analysis,  enzymology*,  metabolism
Myocardium / enzymology
Physical Exertion*
Rats
Rats, Inbred Strains
Triglycerides / analysis,  metabolism*
Grant Support
ID/Acronym/Agency:
AM-17357/AM/NIADDK NIH HHS; HD-10987/HD/NICHD NIH HHS; KO4 AM-00216/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Triglycerides; EC 3.1.1.34/Lipoprotein Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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