Document Detail


Lipoprotein lipase activity and lipolysis after swim training in obese Zucker rats.
MedLine Citation:
PMID:  6638216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obese and lean Zucker rats, 7 wk old, were swim trained or kept sedentary. Another group of obese rats was food restricted and exercised. Half the rats were killed after training for 8 wk, the remainder were retired and killed after an additional 8 wk. Neither treatment decreased adipocyte size in obese rats. Although basal lipolysis per cell was elevated in obese rats, their adipocytes were insensitive to epinephrine at 15 and 23 wk of age. Exercise training did not affect lipolysis. At all ages, adipose lipoprotein lipase (LPL) capacity was higher in obese relative to lean rats. In obese rats, swim training and exercise plus food restriction increased adipose and gastrocnemius LPL activity and depressed plasma insulin and triglyceride levels. All effects of exercise were transient. Thus, exercise training improved some of the metabolic disturbances in the Zucker obese rat but did not normalize adipocyte size, LPL activity, or lipolysis.
Authors:
J L Walberg; M R Greenwood; J S Stern
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  245     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R706-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Animals
Body Weight
Female
Kinetics
Lipolysis*
Lipoprotein Lipase / metabolism*
Physical Exertion*
Rats
Rats, Zucker
Swimming
Grant Support
ID/Acronym/Agency:
AM-18899/AM/NIADDK NIH HHS; AM-HL-07355/AM/NIADDK NIH HHS; HD-12637/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
EC 3.1.1.34/Lipoprotein Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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