Document Detail


Lipoprotein (a) in young individuals as a marker of the presence of ischemic heart disease and the severity of coronary lesions.
MedLine Citation:
PMID:  16585023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to evaluate whether high levels and small isoforms of lipoprotein (a) [Lp(a)] are markers of risk of early myocardial infarction and markers of the severity of coronary atherosclerosis. Lp(a) levels and small apo(a) isoforms were higher in 222 patients than in 199 controls (p<0.001). In patients, Lp(a)> or =30 mg/dL was associated with the presence of coronary lesions (p=0.007) and the severity of coronary atherosclerosis (p=0.002). The present study suggests that Lp(a) levels and small isoforms are markers of early myocardial infarction and that Lp(a) levels > or =30 mg/dL are associated with severe patterns of coronary atherosclerosis.
Authors:
Esther Zorio; Cristina Falco; Miguel A Arnau; Francisco España; Ana Osa; Luis A Ramon; Remedios Castello; Luis Almenar; Miguel A Palencia; Amparo Estelles
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Haematologica     Volume:  91     ISSN:  1592-8721     ISO Abbreviation:  Haematologica     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-04     Completed Date:  2006-06-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  562-5     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Research Centre, Hospital Universitario La Fe, Valencia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Case-Control Studies
Coronary Artery Disease
Female
Humans
Lipoprotein(a) / blood*
Male
Middle Aged
Myocardial Ischemia / diagnosis,  pathology*
Protein Isoforms
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipoprotein(a); 0/Protein Isoforms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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