Document Detail

Lipoprotein (a) in Behçet's disease as an indicator of disease activity and in thrombotic complications.
MedLine Citation:
PMID:  11284488     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the utility of plasma concentrations of lipoprotein (a) (Lp(a)) as an indicator of disease activity in Behçet's disease and to investigate its role in thrombotic complications of this disease. METHODS: 30 patients (19 male, 11 female) with Behçet's disease (8 active, 22 inactive) were enrolled in the study group and 30 healthy individuals (16 male, 14 female) in the control group. Seven of the inactive Behçet's disease patients had a history of thrombotic complications. The disease activity was evaluated by clinical manifestations (oral aphthous lesions, genital ulcerations, uveitis and vasculitis) and laboratory investigations (leucocyte count, lipoprotein (a), C-reactive protein (CRP), complement 3 (C3) and complement 4 (C4) concentrations). RESULTS: Plasma Lp(a) and other acute phase reactant concentrations were significantly higher in the study group than in the controls (p < 0.01). These concentrations were also higher during the active period of the disease than during the inactive phase (p < 0.01). Lp(a) concentrations were significantly correlated with concentrations of other acute phase reactants. There was no difference between the groups with and without thrombotic complications for any of these measurements. CONCLUSIONS. Plasma levels of Lp(a) might be an indicator of disease activity in Behçet's disease. There is no correlation between Lp(a) levels and thrombotic sequela in inactive Behçet's disease. However, further studies are needed on the thrombogenic role of Lp(a) during the active phase of thrombophlebitis, and in larger series.
O Gürbüz; Y Ozdemir; C B Coşar; G Kural
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  11     ISSN:  1120-6721     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    2001 Jan-Mar
Date Detail:
Created Date:  2001-04-03     Completed Date:  2001-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  62-5     Citation Subset:  IM    
Ankara Numune Hospital, Eye Clinic 2, Turkey.
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MeSH Terms
Acute-Phase Proteins / metabolism
Behcet Syndrome / blood*,  complications
Lipoprotein(a) / blood*
Middle Aged
Thrombosis / blood*,  complications
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Lipoprotein(a)

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