| Lipoprotein glomerulopathy-like disease in a patient with type III hyperlipoproteinemia due to apolipoprotein E2 (Arg158 Cys)/3 heterozygosity. | |
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MedLine Citation:
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PMID: 17593519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 77-year-old woman developed nephrotic syndrome associated with type III hyperlipoproteinemia (III HLP) and increased apolipoprotein E (apo E). Apo E analysis disclosed E2/E3 heterozygosity in phenotypic and genotypic expressions, without any other mutations. A renal biopsy showed intraluminal and subendothelial thrombus-like deposits in the dilated capillary loops of the glomerulus that stained positive for lipids and apo E. Electron microscopy revealed tiny granular particles in the capillary lumina, as well as between the glomerular basement membrane and the endothelial cells. It was therefore concluded that III HLP associated with apo E2/E3 heterozygosity could induce lipoprotein glomerulopathy-like disease and nephrotic syndrome. |
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Authors:
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Miho Karube; Kimimasa Nakabayashi; Yasunori Fujioka; Ken Yoshihara; Akira Yamada; Akira Matsunaga; Takao Saito |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-06-28 |
Journal Detail:
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Title: Clinical and experimental nephrology Volume: 11 ISSN: 1342-1751 ISO Abbreviation: Clin. Exp. Nephrol. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-26 Completed Date: 2007-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: Japan |
Other Details:
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Languages: eng Pagination: 174-9 Citation Subset: IM |
Affiliation:
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Division of Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-0061, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Apolipoprotein E2 / genetics*, metabolism Female Gene Expression Regulation Heterozygote* Humans Hyperlipoproteinemia Type III / complications*, genetics Kidney Glomerulus / metabolism, pathology Nephrotic Syndrome / diagnosis, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein E2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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