| Lipoprotein (a): an emerging risk factor for atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 2667728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lipoprotein (a) is an antigenic variant of low density lipoprotein and is present in the plasma of most people. Many epidemiologic studies from Europe and North America have found that when plasma levels of lipoprotein (a) exceed 0.20 g/L, there is a significantly higher risk of coronary and cerebrovascular atherosclerosis. Until recently, there has been little insight into the function of lipoprotein (a) or its potential atherogenic mechanism. Molecular biological studies have shown that the characteristic protein of lipoprotein (a), called apolipoprotein (a), strongly resembles plasminogen, the precursor of the natural anticoagulant plasmin. Furthermore, there is emerging evidence that lipoprotein (a) is the missing link between the lipoprotein and coagulation systems, acting perhaps as a vehicle which delivers cholesterol to the site of intravascular damage, or as an inhibitor of plasminogen activation at the site of an evolving thrombus. |
| | |
Authors:
|
R A Hegele |
Related Documents
:
|
1827568 - Serum lipids, lipoproteins, and apolipoproteins during postmenopausal estrogen replacem... 1326708 - Hormone replacement therapy: lipid responses to continuous combined oestrogen and proge... 15587758 - Plasma adiponectin levels in post-menopausal women receiving hormone replacement therapy. 2775768 - Seasonal variations of plasma lipids and lipoproteins in the hedgehog, an animal model ... 3134778 - Decreased tsh response to trh induced by amiodarone. 17065068 - Effect of beer ingestion on the plasma concentrations and urinary excretion of purine b... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: The Canadian journal of cardiology Volume: 5 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 1989 Jun-Aug |
Date Detail:
|
Created Date: 1989-09-12 Completed Date: 1989-09-12 Revised Date: 2008-04-09 |
Medline Journal Info:
|
Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: CANADA |
Other Details:
|
Languages: eng Pagination: 263-5 Citation Subset: IM |
Affiliation:
|
Howard Hughes Medical Institute, University of Utah, Salt Lake City. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Arteriosclerosis
/
blood* Cross-Sectional Studies Humans Lipoproteins / blood*, genetics, physiology Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Lipoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transesophageal echocardiography: experience of a Canadian centre.
Next Document: Actions of nisoldipine in cardiovascular disease.