Document Detail

Lipoprotein (a) concentrations in patients with familial combined hyperlipidemia and hypertension.
MedLine Citation:
PMID:  10431554     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Lipoprotein (a) (Lp(a)) is an independent risk factor for coronary heart disease (CHD), and its association with hyperlipidemia and/or hypertension greatly increases the risk of premature CHD. METHODS: The present study assessed plasma concentrations of Lp(a) in hyperlipidemic subjects from families with well-defined familial combined hyperlipidemia (FCH) (n = 262) and from patients with hypertension (n = 168), and to compare it with Lp(a) plasma levels in healthy volunteers (n = 371). Lp(a) concentrations were measured using a specific radioimmunoassay. RESULTS: The Lp(a) plasma concentrations were similar in FCH patients (median 204 mg/l, range 16-2163 mg/l) and in the control group (155, 16-1846 mg/l; P > 0.05). The Lp(a) levels in patients with hypertension (157, 10-1985 mg/l) did not differ from those of controls (P > 0.05). The Lp(a) concentrations were similar in patients with essential hypertension (EH) and normal lipid levels, and in hyperlipidemic EH patients. A tendency towards higher levels of Lp(a) was observed in patients with secondary hypertension due to renal artery stenosis (RAS) (n = 26, Lp(a) 232, 16-1110 mg/l), but this was not statistically significant. CONCLUSIONS: Plasma concentrations of Lp(a) are similar in patients with FCH, with EH, either normo- or hyperlipidemic, and with RAS, when compared with healthy controls. However, measuring the Lp(a) levels in patients with either hyperlipidemia or hypertension remains important for assessing the risk potential for severe atherosclerosis in these patients.
R T Netea; M G Netea; S J Bredie; P N Demacker; N Hancu; T Thien; A F Stalenhoef
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  55     ISSN:  0300-2977     ISO Abbreviation:  Neth J Med     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-20     Completed Date:  1999-08-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Department of Medicine, University Hospital Nijmegen, The Netherlands.
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MeSH Terms
Cholesterol / blood
Coronary Artery Disease / etiology
Hyperlipidemia, Familial Combined / blood*,  complications*
Hypertension / blood*,  complications*
Hypertension, Renovascular / blood
Lipoprotein(a) / blood*
Middle Aged
Risk Factors
Triglycerides / blood
Reg. No./Substance:
0/Lipoprotein(a); 0/Triglycerides; 57-88-5/Cholesterol

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