Document Detail


Lipoprotein-associated phospholipase A(2) level in patients with Behçet's disease.
MedLine Citation:
PMID:  22755553     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background  Behçet's disease (BD) is a chronic multisystem inflammatory disorder characterized by vasculitis. Vasculitis is thought to underlie many of the clinical manifestations of Behçet's disease. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2) ) is a highly specific biomarker for vascular inflammation, and has low biological variability. Those features make it more attractive than other inflammatory markers including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which may reflect systemic inflammation non-specifically. Objectives  It was aimed to investigate circulating Lp-PLA(2) levels and its relationship with CRP and ESR in patients with BD by considering disease activity. Methods  Study group included 72 patients with BD (34 men and 38 women with a mean age of 35.3 years) and 30 sex- and age-matched healthy subjects (15 men and 15 women with a mean age 32.6 years). Patients group included 40 patients with active and 32 patients with inactive BD. Results  Lp-PLA(2) , CRP and ESR levels were found to be significantly higher in patient group than controls. In addition, those levels were also significantly higher in patients with active BD than in patients with inactive disease. Lp-PLA(2) showed positive correlations with CRP and ESR (r = 0.63, P < 0.05 and r = 0.33, P < 0.05 respectively). Lp-PLA(2) also showed significant important area under curve (AUC) value (0.779), besides CRP (0.941) and ESR (0.888). Optimum cut-off value was obtained as 218.5 ng/mL. Conclusions  It was concluded that Lp-PLA(2) may be a new useful biomarker to evaluate clinical or subclinical activity of the disease besides CRP and ESR.
Authors:
A Orem; S Yayli; D A Arıca; B Akcan; F B Yücesan; S Bahadir
Related Documents :
7891423 - Low levels of serum apolipoprotein a i and a ii in senile dementia.
22073843 - Subacute polyneuropathy in a patient undergoing peritoneal dialysis: clinical features ...
17632713 - Imaging of corticobasal degeneration syndrome.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-3
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  -     ISSN:  1468-3083     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.
Affiliation:
Departments of Biochemistry Dermatology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Effects of Chronic Periodontitis and Its Treatment on the Subsequent Risk of Psoriasis.
Next Document:  Soluble urokinase-type plasminogen activator receptor (suPAR) in patients with suspected infection i...