Document Detail


Lipoprotein CD0873 is a Novel Adhesin of Clostridium difficile.
MedLine Citation:
PMID:  24482399     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Clostridium difficile is a cause of antibiotic-associated diarrhoea (AAD) and colitis, a healthcare-associated intestinal disease. Colonisation of the gut is a critical step in the course of infection. The C. difficile lipoprotein CD0873 was identified as a putative adhesin through a bioinformatics approach. Surface exposure of CD0873 was confirmed and a CD0873 mutant was generated. The CD0873 mutant showed a significant reduction in adherence to Caco-2 cells and wild-type bacteria pre-incubated with anti-CD0873 antibodies showed significantly decreased adherence to Caco-2 cells. In addition, we demonstrated that purified recombinant CD0873 protein alone associates with Caco-2 cells. This is the first definitive identification of a C. difficile adhesin which now allows work to devise improved measures for preventing and treating disease.
Authors:
Andrea Kovacs-Simon; Rosanna Leuzzi; Magdalena Kasendra; Nigel Minton; Richard W Titball; Stephen L Michell
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-29
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  -     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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