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Lipopolysaccharide and soluble CD14 in cord blood plasma are associated with prematurity and chorioamnionitis.
MedLine Citation:
PMID:  24135785     Owner:  NLM     Status:  Publisher    
Background:Lipopolysaccharide (LPS), an endotoxin of gram-negative bacteria, causes preterm birth in animals and has been implicated as a factor triggering preterm labor and systemic complications in humans. Little is known regarding LPS in the cord blood (CB) of term and preterm infants and its association with maternal and fetal characteristics.Methods:CB was obtained from term (n=15) and preterm infants (n=76) after delivery. Plasma levels of LPS, C-Reactive Protein (CRP) and soluble CD14 (sCD14) were measured using commercially available kits (Limulus Amebocyte Lysate (LAL) and ELISA). Four linear regression models were created in order to identify independent variables that predict plasma LPS levels.Results:Analyte levels were significantly higher in preterm versus term infant CB: LPS (24.48 vs. 1 pg/ml; p=0.0009), CRP (87.9 vs. 47 ng/ml; p=0.01) and sCD14 (0.32 vs.0.35 µg/ml; p=0.013). There was a (significant) positive correlation between CB LPS levels and gestational age, birth weight, CRP levels, sCD14 levels and association with both clinical and histological chorioamnionitis.Conclusion:Our data suggest that LPS is associated with preterm labor and inflammation (CRP elevation and chorioamnionitis). These findings may be relevant to the understanding of the role of LPS in prematurity and its role in preterm morbidities.Pediatric Research (2013); doi:10.1038/pr.2013.182.
Denise G Martinez-Lopez; Nicholas T Funderburg; Adam Cerissi; Reema Rifaie; Laura Aviles-Medina; Braulio J Llorens-Bonilla; John Sleasman; Angel A Luciano
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-17
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL.
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