| Lipopolysaccharide induces fever and decreases tail flick latency in awake rats. | |
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MedLine Citation:
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PMID: 8361627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In humans, somatic aches and pains are frequently reported during fever. To determine whether exogenous pyrogen administration increases nociceptive responsiveness in rats, the tail flick reflex evoked by noxious heat was compared in animals that received an intraperitoneal injection of exogenous pyrogen (lipopolysaccharide) or vehicle (saline). There were no differences in skin temperature between lipopolysaccharide- and vehicle-injected rats. Awake rats injected with lipopolysaccharide exhibited an increase in colonic temperature and a decrease in tail flick latency when compared to vehicle-injected rats. Neural events that trigger fever may therefore also modulate nociceptive responsiveness. |
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Authors:
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P Mason |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 154 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-09-27 Completed Date: 1993-09-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 134-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fever / chemically induced* Hot Temperature Lipopolysaccharides / pharmacology* Male Nociceptors / drug effects Pain / chemically induced* Pain Measurement / drug effects Rats Rats, Sprague-Dawley Reaction Time / drug effects Skin Temperature / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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