Document Detail

Lipopolysaccharide-induced suppressor cells for delayed-type hypersensitivity to herpes simplex virus: nature of suppressor cell and effect on pathogenesis of herpes simplex.
MedLine Citation:
PMID:  6092271     Owner:  NLM     Status:  MEDLINE    
Treatment of mice with LPS at the time of priming with herpes simplex virus type 1 (HSV1) causes the preferential activation of virus-specific T suppressor (Ts) cells. These Ts cells can transfer suppression to the efferent limb of a DTH response. Priming under these conditions is associated with enhanced cell-recruitment to the inoculation site, but had no effect on virus clearance. The induction of suppression was abrogated by pretreatment of mice with cyclophosphamide or indomethacin. LPS had no effect on the antibody response to HSV1 during acute infection, although treated mice showed a raised antibody titre one month after inoculation. Susceptible mice inoculated with HSV1 and given LPS showed protection, both from lethal herpes encephalitis and from demyelination within the CNS as reflected by ear paralysis. These results imply that, during some stages of acute infection, T cell effector mechanisms may themselves mediate tissue damage. At such times, Ts cells may perform a beneficial role leading to a reduction in pathology.
D M Altmann; W A Blyth
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunology     Volume:  53     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-18     Completed Date:  1984-12-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  473-80     Citation Subset:  IM    
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MeSH Terms
Antibodies, Viral / biosynthesis
Cell Movement / drug effects
Cyclophosphamide / pharmacology
Herpes Simplex / immunology*
Hypersensitivity, Delayed*
Immune Tolerance / drug effects
Immunization, Passive
Indomethacin / pharmacology
Lipopolysaccharides / pharmacology*
Lymphocyte Activation
Mice, Inbred Strains
Simplexvirus / immunology
T-Lymphocytes, Regulatory / immunology*
Reg. No./Substance:
0/Antibodies, Viral; 0/Lipopolysaccharides; 50-18-0/Cyclophosphamide; 53-86-1/Indomethacin

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