| Lipopolysaccharide-induced fever in rats prolonged by a needle prick. | |
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MedLine Citation:
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PMID: 9201549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effect of an abdominal prick with a needle on LPS-induced fever in freely-moving rats. LPS was injected intraperitoneally by the following 3 methods: 1) through a hypodermic needle pricked into the abdominal cavity, 2) through a catheter chronically indwelt in the abdominal cavity, and 3) through a catheter chronically indwelt in the abdominal cavity immediately after an abdominal prick was made. In the second method, core body temperature (Tb) began to rise about 1 h after the injection, reaching a maximal level at around 2.5 h and decreasing gradually thereafter. In the first and third methods, Tb rose again to make a second peak after making the first peak of fever. This was the same when LPS was injected through a hypodermic needle pricked into the abdominal cavity under restrained condition. These results suggest that the abdominal prick with a needle is responsible for the development of the second peak (or prolongation) of LPS-fever in rats. |
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Authors:
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N Sugimoto; O Shido; S Sakurada; T Nagasaka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Japanese journal of physiology Volume: 47 ISSN: 0021-521X ISO Abbreviation: Jpn. J. Physiol. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-09-15 Completed Date: 1997-09-15 Revised Date: 2007-03-21 |
Medline Journal Info:
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Nlm Unique ID: 2985184R Medline TA: Jpn J Physiol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 199-204 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Medicine, Kanazawa University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen
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physiology Abdominal Injuries / physiopathology Analysis of Variance Animals Body Temperature / physiology* Catheters, Indwelling Fever / chemically induced* Injections, Intraperitoneal Lipopolysaccharides / administration & dosage, toxicity* Male Needlestick Injuries / physiopathology* Peritoneal Cavity / injuries, physiology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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