| Lipopolysaccharide-induced cytokine production in obsessive-compulsive disorder and generalized social anxiety disorder. | |
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MedLine Citation:
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PMID: 20452055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immune system is implicated in the pathophysiology of various psychiatric disorders. In anxiety disorders such as obsessive-compulsive disorder (OCD) and generalized social anxiety disorder (GSAD), immunological findings are equivocal and sparse. In this study, we investigated the lipopolysaccharide (LPS)- stimulated cytokine levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8) by peripheral blood leukocytes in 26 OCD patients, 26 GSAD patients, and 52 healthy controls. We found that leukocytes of OCD patients produced less IL-6 compared with matched controls, whereas no cytokine differences were found between GSAD patients and matched controls. When both patient groups were compared, a trend toward lower IL-6 levels in OCD patients was observed. This supports the idea of immunological involvement in the pathophysiology of OCD and suggests that GSAD and OCD might be different in immunological respect. |
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Authors:
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Sjoerd Fluitman; Damiaan Denys; Nienke Vulink; Sara Schutters; Cobi Heijnen; Herman Westenberg |
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Publication Detail:
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Type: Journal Article Date: 2010-05-07 |
Journal Detail:
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Title: Psychiatry research Volume: 178 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 313-6 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. s.fluitman@umcutrecht.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anxiety Disorders / immunology, pathology* Case-Control Studies Cytokines / metabolism* Female Humans Leukocytes / drug effects*, immunology Lipopolysaccharides / pharmacology* Male Middle Aged Obsessive-Compulsive Disorder / immunology, pathology* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Lipopolysaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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