| Lipopolysaccharide-evoked HSPA12B expression by activation of MAPK cascade in microglial cells of the spinal cord. | |
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MedLine Citation:
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PMID: 20488464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The 70-kDa family of heat shock proteins (HSP70), in particular, plays a vital role in cellular protection and has been detected in various tissues subject to stress. HSPA12B is the newest member of the HSP70 family but is distinct from the HSP70 family. In this study, we elucidated the dynamic expression changes and localization of HSPA12B in lipopolysaccharide (LPS)-induced neuroinflammatory processes in adult rats. HSPA12B expression was strongly induced in active microglial cells in inflamed spinal cord. In vitro studies indicated that the up-regulation of HSPA12B may be involved in the subsequent microglia activation following LPS challenge. The elevated HSPA12B expression was regulated by activation of MAPK-p38 and ERK1/2 pathways, less contribution of the SAPK/JNK pathway in microglial cells. Collectively, these results suggested HSPA12B may be important for host defense in microglia-mediated immune response. Understanding the cell signal pathway may provide a novel strategy against inflammatory and immune reaction in neuroinflammtion in CNS. |
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Authors:
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Zhiming Cui; Ping Wang; Linlin Sun; Haiou Liu; Junling Yang; Xiaohong Li; Lihua Kang; Yeqing Huang; Aiguo Shen; Chun Cheng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-20 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 294 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 29-37 Citation Subset: IM |
Copyright Information:
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Crown Copyright 2010. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Orthopaedics, The Second Affiliated Hospital of Nantong University, The Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu Province 226001, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line HSP70 Heat-Shock Proteins / metabolism* JNK Mitogen-Activated Protein Kinases / metabolism Lipopolysaccharides / immunology Lumbar Vertebrae MAP Kinase Signaling System* Male Microglia / enzymology, immunology, metabolism* Mitogen-Activated Protein Kinase 1 / metabolism Mitogen-Activated Protein Kinase 3 / metabolism Myelitis / enzymology, metabolism* Rats Rats, Sprague-Dawley Spinal Cord / enzymology, immunology, metabolism* Time Factors Up-Regulation p38 Mitogen-Activated Protein Kinases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/HSP70 Heat-Shock Proteins; 0/HSPA12B protein, rat; 0/Lipopolysaccharides; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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