| Lipophilicity and antiproliferative activity profiling of 2-benzylidencycloalkanones. | |
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MedLine Citation:
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PMID: 17644496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High performance liquid chromatographic (HPLC) method has been developed to separate the members of a library including 24 benzylidenecycloalkanone-type structures and to characterize their lipophilicity. The experimental lipophilicity data (k) of the compounds have been compared with their calculated lipophilicity parameters (CLOGP). In general, good correlations between the measured and calculated lipophilicities have been found and these results were in good accordance with our previously data obtained in case of structurally related molecular libraries. In addition, cytotoxicity screening has been performed to determine the antiproliferative activity of these compounds. Some of the investigated compounds possessed noticeable inhibitory potential. Based on the correlation between the antiproliferative activity and experimentally determined lipophilicity of the molecules investigated, limited structural demands to obtain more potent compounds can be exhibited to support the synthetic design. |
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Authors:
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Balázs Hallgas; Zsófia Dobos; Attila Agócs; Miklós Idei; György Kéri; Tamás Loránd; György Mészáros |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-02 |
Journal Detail:
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Title: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Volume: 856 ISSN: 1570-0232 ISO Abbreviation: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-31 Completed Date: 2007-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101139554 Medline TA: J Chromatogr B Analyt Technol Biomed Life Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 148-55 Citation Subset: IM |
Affiliation:
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Hungarian Academy of Sciences, Peptidbiochemical Research Group in Semmelweis University, Department of Medical Chemistry, H-1088 Budapest, Puskin u. 9, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkanes
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pharmacology* Cell Proliferation / drug effects* Chromatography, High Pressure Liquid Lipids / chemistry* Quantitative Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Alkanes; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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