| Lipophilic peptides: synthesis of lauroyl thyrotropin-releasing hormone and its biological activity. | |
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MedLine Citation:
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PMID: 1866381 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thyrotropin-releasing hormone (TRH) was derivatized by chemical attachment of lauric acid to the N-terminal pyroglutamyl group. The product was confirmed to be more lipophilic than TRH by high-performance liquid chromatography and measurement of partition coefficients. The central nervous system activity and endocrine activity of the lauroyl derivative were only slightly reduced, to 81 and 64% of the parent TRH, respectively. Lipophilic derivatization may be generally applicable to transmembrane delivery of peptides. |
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Authors:
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S Muranishi; A Sakai; K Yamada; M Murakami; K Takada; Y Kiso |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmaceutical research Volume: 8 ISSN: 0724-8741 ISO Abbreviation: Pharm. Res. Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-09-09 Completed Date: 1991-09-09 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8406521 Medline TA: Pharm Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 649-52 Citation Subset: IM |
Affiliation:
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Department of Biopharmaceutics, Kyoto Pharmaceutical University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Male Mice Mice, Inbred ICR Molecular Sequence Data Rats Rats, Inbred Strains Sleep / drug effects Thyrotropin / secretion Thyrotropin-Releasing Hormone / analogs & derivatives*, chemical synthesis, chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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