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Lipophilic Hydroxytyrosol Esters: Fatty Acid Conjugates for Potential Topical Administration.
MedLine Citation:
PMID:  22014120     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hydroxytyrosol is a potent antioxidant natural molecule isolated from olive leaves and fruits. The presence of three hydroxy groups in its structure poses a limit for the topical application of this lead compound. A set of hydroxytyrosol conjugates with fatty acids at different molecular weights were synthesized under mild conditions. The topical delivery features of this new set of antioxidant molecules were evaluated as a function of their permeation profiles through the human stratum corneum and viable epidermis membranes. A dependence on their partition coefficients, their molecular weights, and their isometric configurations was then postulated. Encouraging results prompt further investigations on the polyfunctional role that hydroxytyrosol conjugates could have as agents in both anti-inflammatory and antioxidant therapies.
Authors:
Antonio Procopio; Christian Celia; Monica Nardi; Manuela Oliverio; Donatella Paolino; Giovanni Sindona
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-20
Journal Detail:
Title:  Journal of natural products     Volume:  -     ISSN:  1520-6025     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Dipartimento Farmacobiologico, Università Magna Græcia di Catanzaro Complesso Ninì Barbieri , 88021, Roccelletta di Borgia (CZ), Italy.
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