| Lipophilic 99mTc-nitride radiopharmaceuticals as potential myocardial imaging agents. | |
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MedLine Citation:
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PMID: 1917524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monocationic 99mTc-nitrido complexes of a variety of diphosphine ligands have been prepared and the in vivo distribution of such cations has been examined in Sprague-Dawley rats. These complexes show initially high myocardial uptake with subsequent wash-out in this animal model. The lack of myocardial retention can be attributed to the facile in vivo reduction of these cations. |
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Authors:
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J R Dilworth; C M Archer; I A Latham; J D Kelly; D V Griffiths; D C York; P M Mahoney; B Higley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Volume: 18 ISSN: 0883-2897 ISO Abbreviation: Int J Rad Appl Instrum B Publication Date: 1991 |
Date Detail:
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Created Date: 1991-11-21 Completed Date: 1991-11-21 Revised Date: 2008-02-21 |
Medline Journal Info:
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Nlm Unique ID: 8611098 Medline TA: Int J Rad Appl Instrum B Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 547-50 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, Thin Layer Heart / radionuclide imaging* Ligands Lipids / chemistry Male Organotechnetium Compounds / diagnostic use* Phosphines / diagnostic use* Rats Rats, Inbred Strains Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Lipids; 0/Organotechnetium Compounds; 0/Phosphines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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