Document Detail


Lipomobilization in periparturient dairy cows influences the composition of plasma nonesterified fatty acids and leukocyte phospholipid fatty acids.
MedLine Citation:
PMID:  20494158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The periparturient period is characterized by sudden changes in metabolic and immune cell functions that predispose dairy cows to increased incidence of disease. Metabolic changes include alterations in the energy balance that lead to increased lipomobilization with consequent elevation of plasma nonesterified fatty acids (NEFA) concentrations. The objective of this study was to establish the influence of lipomobilization on fatty acid profiles within plasma lipid fractions and leukocyte phospholipid composition. Blood samples from 10 dairy cows were collected at 14 and 7 d before due date, at calving, and at 7, 14, and 30 d after calving. Total lipids and lipid fractions were extracted from plasma and peripheral blood mononuclear cells. The degree of lipomobilization was characterized by measurement of plasma NEFA concentrations. The fatty acid profile of plasma NEFA, plasma phospholipids, and leukocyte phospholipids differed from the composition of total lipids in plasma, where linoleic acid was the most common fatty acid. Around parturition and during early lactation, the proportion of palmitic acid significantly increased in the plasma NEFA and phospholipid fractions with a concomitant increase in the phospholipid fatty acid profile of leukocytes. In contrast, the phospholipid fraction of long-chain polyunsaturated fatty acids in leukocytes was diminished during the periparturient period, especially during the first 2 wk following parturition. This study showed that the composition of total plasma lipids does not necessarily reflect the NEFA and phospholipid fractions in periparturient dairy cows. These findings are significant because it is the plasma phospholipid fraction that contributes to fatty acid composition of membrane phospholipids. Increased availability of certain saturated fatty acids in the NEFA phospholipid fractions may contribute to altered leukocyte functions during the periparturient period.
Authors:
G A Contreras; N J O'Boyle; T H Herdt; L M Sordillo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of dairy science     Volume:  93     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2508-16     Citation Subset:  IM    
Copyright Information:
2010 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824, USA.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animals
Cattle / metabolism*,  physiology
Fatty Acids / analysis*
Fatty Acids, Monounsaturated / analysis,  blood
Fatty Acids, Nonesterified / blood*
Female
Leukocytes / chemistry*
Lipid Metabolism / physiology*
Parturition / metabolism,  physiology
Phospholipids / analysis*,  blood
Postpartum Period / metabolism,  physiology
Pregnancy
Pregnancy, Animal / metabolism*,  physiology
Stearic Acids / analysis,  blood
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Nonesterified; 0/Phospholipids; 0/Stearic Acids; 2091-29-4/palmitoleic acid; 57-11-4/stearic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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