| Lipolytic effects of B-type natriuretic peptide(1-32) in adipose tissue of heart failure patients compared with healthy controls. | |
| | |
MedLine Citation:
|
PMID: 21884948 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVES: Our goal was to examine the role of B-type natriuretic peptide (BNP) in lipolysis regulation in heart failure (HF) patients. BACKGROUND: Enhanced adipose tissue lipolysis can contribute to myocardial lipid overload, insulin resistance, and cachexia in advanced HF. Natriuretic peptides were recently recognized to stimulate lipolysis in healthy subjects. METHODS: Ten nondiabetic HF patients (New York Heart Association functional class III, 50% nonischemic etiology) and 13 healthy subjects (control subjects) of similar age, sex, and body composition underwent a microdialysis study of subcutaneous abdominal adipose tissue. Four microdialysis probes were simultaneously perfused with 0.1 μM BNP(1-32,) 10 μM BNP(1-32), 10 μM norepinephrine (NE) or Ringer's solution. Outgoing dialysate glycerol concentration (DGC) was measured as an index of lipolysis. RESULTS: Spontaneous lipolysis was higher in HF patients compared with control subjects (DGC: 189 ± 37 μmol/l vs. 152 ± 35 μmol/l, p < 0.01). Response to NE was similar (p = 0.35) in HF patients and control subjects (DGC increase of 1.7 ± 0.2-fold vs. 1.7 ± 0.4-fold). BNP(1-32) 10 μM markedly increased lipolysis in both HF patients and control subjects (DGC increase of 2.8 ± 0.5-fold vs. 3.2 ± 0.3-fold), whereas the response to 0.1 μM BNP(1-32) was more pronounced in HF patients (p = 0.02). In HF patients, spontaneous lipolysis positively correlated with insulin resistance and the response to BNP(1-32) negatively correlated with adiposity. CONCLUSIONS: BNP(1-32) exerts strong lipolytic effects in humans. Despite marked elevation of plasma immunoreactive BNP, the responsiveness of adipose tissue to BNP(1-32) is not attenuated in HF, possibly reflecting a deficiency of endogenous bioactive BNP. Lipolytic effects of BNP can contribute to excessive fatty acid mobilization in advanced HF. |
| | |
Authors:
|
Jan Polak; Martin Kotrc; Zuzana Wedellova; Antonin Jabor; Ivan Malek; Josef Kautzner; Ludmila Kazdova; Vojtech Melenovsky |
Related Documents
:
|
7565068 - Long-term outcome after whiplash injury. a 2-year follow-up considering features of inj... 21847648 - Microdialysis-assessed interstitium alterations during sepsis: relationship to stage, i... 11740258 - Long-term follow-up of prophylactic greenfield filters in multisystem trauma patients. 18580518 - Percutaneous tracheostomy in neurosurgical patients with intracranial pressure monitori... 21137058 - Immunoglobulins are the major glycoproteins involved in the modifications of total seru... 16647238 - Fuzzy role of hyperhomocysteinemia in hemodialysis patients' mortality. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 58 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-09-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1119-25 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Cardiology, Institute of Clinical and Experimental Medicine, IKEM, Prague, Czech Republic; Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland; Department of Sport Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 2nd Internal Medicine Department, University Hospital of Kralovske Vinohrady, Prague, Czech Republic. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical and demographic predictors of outcomes in recent onset dilated cardiomyopathy: results of t...
Next Document: Invasive acute hemodynamic response to guide left ventricular lead implantation predicts chronic rem...