Document Detail

Lipolysis needed for chylomicron uptake?
MedLine Citation:
PMID:  20018939     Owner:  NLM     Status:  MEDLINE    
Despite clinical evidence that postprandial lipemia and chylomicrons could contribute to atherosclerosis, direct evidence is lacking. The study by Weinstein et al(1) provides evidence to suggest that intact chylomicrons might be atherogenic by using genetically altered mice lacking Gpihbp1 protein, which may play a major role in the lipolysis of triglyceride-rich lipoproteins. However, the study does not rule out a contribution by remnants or limited lipolysis by other potential enzymes or pathways. It might be intriguing to determine the contribution of cholesterol derivatives in the chylomicrons to the lesions and the nature of the lesions.
Sampath Parthasarathy
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Publication Detail:
Type:  Comment; Editorial    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  30     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-18     Completed Date:  2010-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-6     Citation Subset:  IM    
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MeSH Terms
Atherosclerosis / metabolism*
Chylomicrons / metabolism*
Lipolysis / physiology*
Triglycerides / metabolism*
Reg. No./Substance:
0/Chylomicrons; 0/Triglycerides
Comment On:
Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):20-3   [PMID:  19815815 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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