| Lipolysis needed for chylomicron uptake? | |
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MedLine Citation:
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PMID: 20018939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite clinical evidence that postprandial lipemia and chylomicrons could contribute to atherosclerosis, direct evidence is lacking. The study by Weinstein et al(1) provides evidence to suggest that intact chylomicrons might be atherogenic by using genetically altered mice lacking Gpihbp1 protein, which may play a major role in the lipolysis of triglyceride-rich lipoproteins. However, the study does not rule out a contribution by remnants or limited lipolysis by other potential enzymes or pathways. It might be intriguing to determine the contribution of cholesterol derivatives in the chylomicrons to the lesions and the nature of the lesions. |
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Authors:
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Sampath Parthasarathy |
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Publication Detail:
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Type: Comment; Editorial |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 30 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-18 Completed Date: 2010-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 5-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / metabolism* Chylomicrons / metabolism* Lipolysis / physiology* Triglycerides / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Chylomicrons; 0/Triglycerides |
| Comments/Corrections | |
Comment On:
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Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):20-3
[PMID:
19815815
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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