Document Detail


Lipoic acid prevents suppression of connective tissue proliferation in the rat liver induced by n-3 PUFAs. A pilot study.
MedLine Citation:
PMID:  11146327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As previously shown, dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) suppress connective tissue proliferation in the rat liver wound concurrent with an elevated level of lipid peroxidation. The present study was undertaken to investigate the influence of alpha-lipoic acid (LA), a natural anti-oxidant, on these effects of n-3 PUFAs. Rats were fed with a commercial pellet diet (control group) or with diets enriched with 10% of sunflower oil (n-6 group) or 10% of fish oil (n-3 group) for 8 weeks followed by addition of LA to the same diets for 10 days. Then a liver thermic wound was induced and the administration of LA was continued for 6 days. The proliferation of the connective tissue, the level of lipid peroxidation and their peroxidizability and the content of prostaglandins E2 and F2alpha were measured in the liver wounds. LA prevented the suppression of connective tissue proliferation in the healing wound induced by n-3 PUFAs, avoided the increase in peroxidation of lipids, reduced peroxidizability of lipids and modulated the decrease in PGE2 and PGF2alpha. The results indicate that dietary LA may prevent the suppression of liver wound healing induced by n-3 PUFAs.
Authors:
A Arend; M Zilmer; T Vihalemm; G Selstam; E Sepp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  44     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  IM    
Affiliation:
Department of Anatomy, University of Tartu, Estonia. arend@ut.ee
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*
Cell Division / drug effects
Connective Tissue / drug effects,  physiology
Fatty Acids, Omega-3 / administration & dosage,  adverse effects*,  metabolism
Lipid Peroxidation / drug effects*
Liver / drug effects,  injuries,  physiology*
Male
Prostaglandins / analysis
Rats
Rats, Wistar
Thioctic Acid / antagonists & inhibitors,  pharmacology*,  physiology
Wound Healing / drug effects*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Fatty Acids, Omega-3; 0/Prostaglandins; 62-46-4/Thioctic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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