Document Detail


Lipoic acid nanoparticles: effect of polymeric stabilizer on appetite suppression.
MedLine Citation:
PMID:  20824957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alpha-lipoic acid (ALA), which is common in the human body, is efficacious in appetite suppression. However, its typical formulations of salt or micronized crystals cannot satisfy the desired bioavailability requirements for appetite suppression due to low absorption and a short plasma half-life. Herein, we describe a new ALA nanoparticulate formulation produced by nano-comminution using polymeric stabilizers, such as hydroxypropyl cellulose, Pluronic F127, and polyvinylpyrrolidone. Nanoparticles of similar sizes did not show any remarkable differences in the in vitro release profiles. However, the in vivo results from food intake studies in mice demonstrated that the hydroxypropyl cellulose case had the largest improved efficacy among the three polymeric stabilizer cases. Compared to the nanosuspension formulations, the powder formulations of nanoparticles had improved efficacy in reducing food intake for six hours, possibly because of the delayed release kinetics. Therefore, the ALA powder formulation of nanoparticles is a candidate to replace the current formulations to achieve proper appetite suppression.
Authors:
Chul Ho Park; Ki-Up Lee; Joong-Yeol Park; Eun-Hee Koh; Hyoun-Sik Kim; Jonghwi Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Die Pharmazie     Volume:  65     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-09     Completed Date:  2010-10-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  580-4     Citation Subset:  IM    
Affiliation:
Department of Chemical Engineering and Materials Science, Chung-Ang University, 221, Heukseok-dong, Dongjak-gu, Seoul 156 756, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants* / administration & dosage
Biological Availability
Cellulose / analogs & derivatives
Chemistry, Pharmaceutical
Eating / drug effects
Excipients
Male
Mice
Mice, Inbred C57BL
Nanoparticles
Particle Size
Poloxamer
Polymers
Povidone
Powders
Solubility
Thioctic Acid / administration & dosage,  pharmacokinetics,  pharmacology*
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Excipients; 0/Polymers; 0/Powders; 106392-12-5/Poloxamer; 62-46-4/Thioctic Acid; 9003-39-8/Povidone; 9004-34-6/Cellulose; 9004-64-2/hydroxypropylcellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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