| Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures. | |
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MedLine Citation:
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PMID: 21062633 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Alpha-lipoic acid has some neuroprotective properties, but this action has not been investigated in models of epilepsy. The aim of the present study was to investigate the protective efficacy of α-lipoic acid (lipoic acid) against pilocarpine-induced cell death through the caspase-dependent or -independent mitochondrial apoptotic pathways. Wistar rats were injected intraperitoneally with 0.9% saline (control group), pilocarpine (400mg/kg, pilocarpine group) alone, or α-lipoic acid (20mg/kg) in association with pilocarpine (400mg/kg) 30min before administration of α-lipoic acid. After the treatments all groups were observed for 24h. Cell death was reduced in lipoic acid-treated rats. Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment. AIF nuclear translocation and subsequent large-scale DNA fragmentation were also decreased in lipoic acid-treated rats. Our study suggests that lipoic acid inhibits both caspase-dependent and -independent apoptotic pathways and may be neuroprotective against hippocampal damage during pilocarpine-induced seizures. |
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Authors:
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Pauline Sousa Dos Santos; Chistiane Mendes Feitosa; Gláucio Barros Saldanha; Adriana da Rocha Tomé; Dejiang Feng; Rivelilson Mendes de Freitas |
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Publication Detail:
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Type: Journal Article Date: 2010-11-06 |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 97 ISSN: 1873-5177 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 531-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory of Research in Experimental Neurochemistry of Federal University of Piaui, Piaui, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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