| Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures. | |
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MedLine Citation:
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PMID: 20433896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic injection of pilocarpine has been shown to induce recurrent seizures and epileptic discharges demonstrated by EEG monitoring. It also has been reported that antioxidants are able to diminish or prevent the occurrence of epileptic discharges induced by pilocarpine through the inhibition of free radical formation and neurotransmitter metabolic alterations. The purpose of this work was to determine the effects of lipoic acid (LA) on the levels of dopamine (DA), serotonin (5-HT), norepinephrine (NE) and subsequent metabolites in the hippocampus of rats after seizure induction by pilocarpine. Seizures dramatically decreased the levels of DA, 5-hydroxyindoleacetic acid (5-HIAA) and NE, whereas significantly increased the levels of neurotransmitter metabolites. The administration of lipoic acid before seizure induction resulted in normalized levels of DA and 5-HA. However, the lipoic acid administration in similar conditions produced a reduction of the metabolites levels when compared with the pilocarpine group. These results suggest that the establishment of acute phase of seizures induced by pilocarpine might be produced by consequent the activation of serotonergic neurons. In addition, the lipoic acid inhibits hyperactivity of this system during the installation of pilocarpine-induced seizures. |
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Authors:
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R M Freitas; J Jordán; D Feng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-28 |
Journal Detail:
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Title: Neuroscience letters Volume: 477 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 129-33 Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Ireland Ltd. |
Affiliation:
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Laboratory of Physiology and Pharmacology of Federal University of Piauí, Picos, Piauí, Brazil. rivelilson@pq.cnpq.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology*, therapeutic use Biogenic Monoamines / metabolism* Dopamine / metabolism Hippocampus / drug effects*, metabolism Hydroxyindoleacetic Acid / metabolism Male Norepinephrine / metabolism Pilocarpine* Rats Rats, Wistar Seizures / chemically induced, drug therapy*, metabolism Serotonin / metabolism Thioctic Acid / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biogenic Monoamines; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid; 62-46-4/Thioctic Acid; 92-13-7/Pilocarpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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