Document Detail


Lipoic acid metabolism in microbial pathogens.
MedLine Citation:
PMID:  20508247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoic acid [(R)-5-(1,2-dithiolan-3-yl)pentanoic acid] is an enzyme cofactor required for intermediate metabolism in free-living cells. Lipoic acid was discovered nearly 60 years ago and was shown to be covalently attached to proteins in several multicomponent dehydrogenases. Cells can acquire lipoate (the deprotonated charge form of lipoic acid that dominates at physiological pH) through either scavenging or de novo synthesis. Microbial pathogens implement these basic lipoylation strategies with a surprising variety of adaptations which can affect pathogenesis and virulence. Similarly, lipoylated proteins are responsible for effects beyond their classical roles in catalysis. These include roles in oxidative defense, bacterial sporulation, and gene expression. This review surveys the role of lipoate metabolism in bacterial, fungal, and protozoan pathogens and how these organisms have employed this metabolism to adapt to niche environments.
Authors:
Maroya D Spalding; Sean T Prigge
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Microbiology and molecular biology reviews : MMBR     Volume:  74     ISSN:  1098-5557     ISO Abbreviation:  Microbiol. Mol. Biol. Rev.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-28     Completed Date:  2010-09-15     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9706653     Medline TA:  Microbiol Mol Biol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-28     Citation Subset:  IM    
Affiliation:
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Room E5132, Baltimore, MD 21205, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apicomplexa / metabolism,  pathogenicity
Bacteria / metabolism,  pathogenicity
Fungi / metabolism,  pathogenicity
Models, Biological
Thioctic Acid / metabolism*
Grant Support
ID/Acronym/Agency:
R01 AI065853/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
62-46-4/Thioctic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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