| Lipoic acid metabolism in microbial pathogens. | |
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MedLine Citation:
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PMID: 20508247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipoic acid [(R)-5-(1,2-dithiolan-3-yl)pentanoic acid] is an enzyme cofactor required for intermediate metabolism in free-living cells. Lipoic acid was discovered nearly 60 years ago and was shown to be covalently attached to proteins in several multicomponent dehydrogenases. Cells can acquire lipoate (the deprotonated charge form of lipoic acid that dominates at physiological pH) through either scavenging or de novo synthesis. Microbial pathogens implement these basic lipoylation strategies with a surprising variety of adaptations which can affect pathogenesis and virulence. Similarly, lipoylated proteins are responsible for effects beyond their classical roles in catalysis. These include roles in oxidative defense, bacterial sporulation, and gene expression. This review surveys the role of lipoate metabolism in bacterial, fungal, and protozoan pathogens and how these organisms have employed this metabolism to adapt to niche environments. |
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Authors:
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Maroya D Spalding; Sean T Prigge |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Microbiology and molecular biology reviews : MMBR Volume: 74 ISSN: 1098-5557 ISO Abbreviation: Microbiol. Mol. Biol. Rev. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-28 Completed Date: 2010-09-15 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9706653 Medline TA: Microbiol Mol Biol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 200-28 Citation Subset: IM |
Affiliation:
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Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Room E5132, Baltimore, MD 21205, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apicomplexa / metabolism, pathogenicity Bacteria / metabolism, pathogenicity Fungi / metabolism, pathogenicity Models, Biological Thioctic Acid / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI065853/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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62-46-4/Thioctic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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