| Lipoic acid: an immunomodulator that attenuates glycinin-induced anaphylactic reactions in a rat model. | |
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MedLine Citation:
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PMID: 20302377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate the attenuation effects of consuming a small dose of lipoic acid on soybean glycinin-induced hypersensitivity using a rat model. Sensitized by gavage with glycinin, weaned rats were orally supplemented with the diet containing 12.5 mug of lipoic acid/g (per diet). Results showed that untreated, sensitized rats demonstrated an increase in the level of serum IgE, the level of histamine release, and incidence of diarrhea and reduced growth performance compared with the controls (P < 0.05). Lipoic acid significantly (P < 0.05) improved growth performance while reducing mast cell numbers, the level of serum IgE, and the level of histamine release. Lipoic acid supplementation altered the balance of cytokines, attenuated the Th2-type immune response, and amended the ratio of CD4(+) to CD8(+) T cells (P < 0.05). Our results suggest that a small dose of lipoic acid has the potential to be an immunomodulator to prevent soybean-induced allergies. |
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Authors:
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Xi Ma; Pingli He; Peng Sun; Pengfei Han |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 58 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 5086-92 Citation Subset: IM |
Affiliation:
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National Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100193, PR China. maxi@cau.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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pharmacology* Anaphylaxis / immunology, prevention & control* Animals Female Globulins / pharmacology* Rats Rats, Sprague-Dawley Soybean Proteins / pharmacology* Thioctic Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Globulins; 0/Soybean Proteins; 62-46-4/Thioctic Acid; 9007-93-6/glycinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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