| Lipoic acid glyco-conjugates, a new class of agents for controlling nonspecific adsorption of blood serum at biointerfaces for biosensor and biomedical applications. | |
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MedLine Citation:
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PMID: 19968241 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The carbohydrate-derived lipoic acid derivatives were studied as protein and cell resistant biomaterials. Six types of carbohydrates were examined for their abilities to reduce nonspecific adsorption of human serum and Hela cell using quartz crystal microbalance. Our data suggested that the structures of carbohydrates play an important role in resisting nonspecific binding. Specifically, the resistance was found to increase in the order lipoic fucose < lipoic mannose < lipoic N-acetyl glucosamine < lipoic glucose < lipoic sialic acid < lipoic galactose, where lipoic galactose derivative resisted most nonspecific adsorption. Furthermore, the combination of lipoic galactose and BSA was the most effective in reducing the adsorption of even undiluted human serum and the attachment of Hela cells while allowing specific binding. Several control experiments have demonstrated that the resistant-ability of mixed lipoic galactose and BSA was comparable to the best known system for decreasing nonspecific adsorption. |
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Authors:
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Yanyan Wang; Kheireddine El-Boubbou; Hovig Kouyoumdjian; Bin Sun; Xuefei Huang; Xiangqun Zeng |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Langmuir : the ACS journal of surfaces and colloids Volume: 26 ISSN: 1520-5827 ISO Abbreviation: Langmuir Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-06-01 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9882736 Medline TA: Langmuir Country: United States |
Other Details:
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Languages: eng Pagination: 4119-25 Citation Subset: IM |
Affiliation:
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Chemistry Department, Oakland University, Rochester, Michigan 48309, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Biosensing Techniques* Electrodes Glycoconjugates / chemistry* Hela Cells Humans Magnetic Resonance Spectroscopy Serum* Thioctic Acid / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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EB000672/EB/NIBIB NIH HHS; GM72667/GM/NIGMS NIH HHS; R01 GM072667-06/GM/NIGMS NIH HHS; R33 EB000672-05/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glycoconjugates; 62-46-4/Thioctic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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