Document Detail


Lipogenesis from glucose-2- 14 C and acetate-1- 14 C in aorta.
MedLine Citation:
PMID:  5124536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipogenesis was measured with glucose-2-(14)C and acetate-1-(14)C in the everted aortas of normal and atherosclerotic rabbits. More glucose-2-(14)C than acetate-1-(14)C was incorporated into lipids in both the normal and the atherosclerotic aorta. Radiocarbon from glucose-2-(14)C appeared mainly in triglycerides and phospholipids with a small amount in cholesteryl esters. Incorporation increased almost threefold with atherosclerosis, most of the radioactivity being in the glycerol moiety; radioactivity was predominantly in carbon 2 of glycerol. About 70% of the acetate-1-(14)C incorporated into phospholipids and triglycerides was in the fatty acids, and the remainder was in glyceride-glycerol; 98% of the radioactivity in cholesteryl esters was in the fatty acid moiety. Incorporation into cholesteryl esters was increased most during the development of atherosclerosis. Fatty acid synthesis was similar from both acetate-1-(14)C and the 2 carbon unit derived from glucose-2-(14)C, viz., predominantly de novo synthesis of fatty acids with 14 and 16 carbon atoms, and elongation for those of 18 carbons and longer.
Authors:
C F Howard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of lipid research     Volume:  12     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1971 Nov 
Date Detail:
Created Date:  1972-02-10     Completed Date:  1972-02-10     Revised Date:  2007-03-20    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  725-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetates / metabolism*
Animals
Aorta / analysis,  metabolism*
Arteriosclerosis / metabolism
Carbon Isotopes
Cholesterol / analysis,  metabolism
Diet, Atherogenic
Fatty Acids / analysis,  metabolism
Female
Glucose / metabolism*
Lipids / analysis,  biosynthesis*
Phospholipids / analysis,  metabolism
Rabbits
Triglycerides / analysis,  metabolism
Chemical
Reg. No./Substance:
0/Acetates; 0/Carbon Isotopes; 0/Fatty Acids; 0/Lipids; 0/Phospholipids; 0/Triglycerides; 50-99-7/Glucose; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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