Document Detail

Lipofuscin is a photoinducible free radical generator.
MedLine Citation:
PMID:  8229462     Owner:  NLM     Status:  MEDLINE    
Despite the association between high concentrations of the age pigment lipofuscin and various age-related pathologies, there is contention as to whether or not the intracellular accumulation of such granules has an adverse effect on cell function. In this paper, we present evidence to indicate that lipofuscin is a photoinducible free radical generator. White light irradiation of lipofuscin granules resulted in the production of superoxide anions, their rate of production increasing with increased light intensity. This effect appeared to be maximal in the blue light region of the spectrum. We speculate that lipofuscin could be detrimental to bodily functions through free radical generation initiated either by light or interaction with endogenous free radicals.
M Boulton; A Dontsov; J Jarvis-Evans; M Ostrovsky; D Svistunenko
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of photochemistry and photobiology. B, Biology     Volume:  19     ISSN:  1011-1344     ISO Abbreviation:  J. Photochem. Photobiol. B, Biol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-07     Completed Date:  1993-12-07     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8804966     Medline TA:  J Photochem Photobiol B     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  201-4     Citation Subset:  IM    
Department of Ophthalmology, University of Manchester, UK.
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MeSH Terms
Cytochrome c Group / chemistry
Free Radicals
Lipofuscin / chemistry*,  radiation effects
Middle Aged
Pigment Epithelium of Eye / chemistry
Reg. No./Substance:
0/Cytochrome c Group; 0/Free Radicals; 0/Lipofuscin; 11062-77-4/Superoxides

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