Document Detail


Lipofuscin and macular degeneration.
MedLine Citation:
PMID:  14604266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The accumulation of the autofluorescent pigment lipofuscin in the retina that occurs with aging has been explained as a side effect of the visual cycle. It occurs when two molecules of all-trans-retinal condense with one molecule of phosphatidylethanolamine in the discs of the rod outer segments, and is followed by uptake into retinal pigment epithelium (RPE) and conversion to the stable A2E, a pyridinium bisretinoid that is toxic to RPE cells. The accumulation of A2E, the major component of lipofuscin causes RPE cell apoptosis, thereby explaining age-related macular degeneration and macular degeneration characteristic of Stargardt disease. The drug isotretinoin (13-cis-retinoic acid) prevents accumulation of A2E in mice by slowing down the visual cycle and might therefore be used to prevent macular degeneration.
Authors:
George Wolf
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  61     ISSN:  0029-6643     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-07     Completed Date:  2004-02-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  342-6     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720-3104, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Humans
Isotretinoin / pharmacology
Lipofuscin / metabolism*
Macular Degeneration / etiology*,  prevention & control
Mice
Pyridinium Compounds / metabolism
Rats
Retinoids / metabolism
Chemical
Reg. No./Substance:
0/A2E compound; 0/Lipofuscin; 0/Pyridinium Compounds; 0/Retinoids; 4759-48-2/Isotretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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