| Lipofuscin and macular degeneration. | |
| | |
MedLine Citation:
|
PMID: 14604266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The accumulation of the autofluorescent pigment lipofuscin in the retina that occurs with aging has been explained as a side effect of the visual cycle. It occurs when two molecules of all-trans-retinal condense with one molecule of phosphatidylethanolamine in the discs of the rod outer segments, and is followed by uptake into retinal pigment epithelium (RPE) and conversion to the stable A2E, a pyridinium bisretinoid that is toxic to RPE cells. The accumulation of A2E, the major component of lipofuscin causes RPE cell apoptosis, thereby explaining age-related macular degeneration and macular degeneration characteristic of Stargardt disease. The drug isotretinoin (13-cis-retinoic acid) prevents accumulation of A2E in mice by slowing down the visual cycle and might therefore be used to prevent macular degeneration. |
| | |
Authors:
|
George Wolf |
Related Documents
:
|
17707566 - The neurobiology of retinoic acid in affective disorders. 14738226 - Retinoic acid induces alveolar regeneration in the adult mouse lung. 1988666 - Bmy 30047: a novel topically active retinoid with low local and systemic toxicity. 8460936 - Regulation of hepatic lecithin: retinol acyltransferase activity by retinoic acid. 658616 - Antiketogenic action of fructose in man. 6689146 - Free nucleosides and bases in the hyperkeratotic epidermis. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Nutrition reviews Volume: 61 ISSN: 0029-6643 ISO Abbreviation: Nutr. Rev. Publication Date: 2003 Oct |
Date Detail:
|
Created Date: 2003-11-07 Completed Date: 2004-02-20 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
|
Languages: eng Pagination: 342-6 Citation Subset: IM |
Affiliation:
|
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720-3104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology* Animals Humans Isotretinoin / pharmacology Lipofuscin / metabolism* Macular Degeneration / etiology*, prevention & control Mice Pyridinium Compounds / metabolism Rats Retinoids / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/A2E compound; 0/Lipofuscin; 0/Pyridinium Compounds; 0/Retinoids; 4759-48-2/Isotretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ketones: metabolism's ugly duckling.
Next Document: Genistein appears to prevent early postmenopausal bone loss as effectively as hormone replacement th...