Document Detail

Lipofuscin in the cerebellar cortex of albino rats: an electron microscopic study.
MedLine Citation:
PMID:  453548     Owner:  NLM     Status:  MEDLINE    
The ultrastructure of autofluorescent, PAS-positive lipofuscin in Purkinje, granule, Golgi epithelial, basket and stellate, microglial and perivascular cells in the cerebellar cortex of senescent rats is described. The membrane-bounded pigment is composed of three elements: 1) electron-lucent homogeneous droplets, 2) a granular matrix and 3) intensely osmiophilic patches. The proportions of these three components vary between cell types and one can grossly differentiate a neuronal and a glial lipofuscin. The lipofuscin granules of stellate and perivascular cells are different from lipofuscin of other cerebellar neurons and glia. It can be concluded from these morphological observations that each cerebellar cell type has its distinct lipofuscin.
H Heinsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anatomy and embryology     Volume:  155     ISSN:  0340-2061     ISO Abbreviation:  Anat. Embryol.     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-08-29     Completed Date:  1979-08-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7505194     Medline TA:  Anat Embryol (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  333-45     Citation Subset:  IM    
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MeSH Terms
Albinism / pathology*
Cerebellar Cortex / ultrastructure*
Lipofuscin / analysis*
Microscopy, Electron
Neuroglia / analysis
Neurons / analysis
Pigments, Biological / analysis*
Purkinje Cells / analysis
Reg. No./Substance:
0/Lipofuscin; 0/Pigments, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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