| Lipodystrophy syndrome and cardiovascular risk factors in children and adolescents infected with HIV/AIDS receiving highly active antiretroviral therapy. | |
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MedLine Citation:
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PMID: 20151093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe lipid profile, body shape changes, and cardiovascular risk factors in children and adolescents infected with HIV/AIDS receiving highly active antiretroviral therapy. METHODS: We investigated 43 children and adolescents being treated with this therapy at the outpatient clinic of pediatric infectious diseases of Instituto Fernandes Figueira/Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. Values of total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were determined. We also performed glucose tolerance test and analyzed body fat distribution, nutritional status, dietary intake, and family history of cardiovascular risk. The statistical analysis was performed using Student's t test. Significance level of p-value was lower than 0.05. RESULTS: We found lipid abnormality in 88.3% and body shape change in 13.9% of the cases. Nutritional status was adequate (81.3%) in most of the study population. Cholesterol intake in children older than 9 years was above the recommended value. CONCLUSION: Prevalence of dyslipidemia and, therefore, risk for cardiovascular diseases were high during the use of highly active antiretroviral therapy. |
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Authors:
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Maria L F Werner; Marcos V da S Pone; Vânia M Fonseca; Célia R M de M Chaves |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Jornal de pediatria Volume: 86 ISSN: 1678-4782 ISO Abbreviation: J Pediatr (Rio J) Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-02-12 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985188R Medline TA: J Pediatr (Rio J) Country: Brazil |
Other Details:
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Languages: eng Pagination: 27-32 Citation Subset: IM |
Affiliation:
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Saúde da Mulher e da Criança, Instituto Fernandes Figueira/Fundação Oswaldo Cruz (IFF/Fiocruz), Rio de Janeiro, RJ, Brazil. mluizafw@iff.fiocruz.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antiretroviral Therapy, Highly Active / adverse effects* Body Fat Distribution / statistics & numerical data Brazil / epidemiology Cardiovascular Diseases / etiology* Child Child, Preschool Female HIV-Associated Lipodystrophy Syndrome / epidemiology*, metabolism Humans Lipids / blood Male Prevalence Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Lipids |
| Comments/Corrections | |
Comment In:
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J Pediatr (Rio J). 2010 Jan-Feb;86(1):3-5
[PMID:
20151098
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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