Document Detail


Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease.
MedLine Citation:
PMID:  18436228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipocalin-type prostaglandin D synthase (L-PGDS), which is responsible for the biosynthesis of prostaglandin (PG) D(2), has been found to be present in the atherosclerotic plaque of the human coronary artery and also to be detectable in human serum. This multicenter cooperative study was designed to establish the diagnostic value of measuring serum L-PGDS for coronary artery disease. The study included 1013 consecutive patients suspected of having stable coronary artery disease who underwent diagnostic coronary angiography. Peripheral blood was collected prior to angiography. The serum level of L-PGDS, as determined by a sandwich ELISA, was 58.1 +/- 2.2, 62.0 +/- 1.8 and 80.6 +/- 2.6 microg/dl for patients with no stenotic lesion (N, n=241), single-vessel coronary artery disease (S, n=351), and multi-vessel coronary artery disease (M, n=421), respectively (N vs. S; P<0.001, S vs. M; P<0.01, N vs. M; P<0.001). Multiple regression analysis indicated that the most powerful independent predictor of the coronary severity score (Gensini Score) was the L-PGDS level (R=0.55, P<0.0001). The serum L-PGDS level is suitable to evaluate the severity of coronary artery disease. The measurement of serum L-PGDS can be a strategy for screening of stable coronary artery disease prior to coronary angiography.
Authors:
Teruo Inoue; Yutaka Eguchi; Tetsuya Matsumoto; Yoshiyuki Kijima; Yoji Kato; Yukio Ozaki; Katsuhisa Waseda; Hiroshi Oda; Kosuke Seiki; Koichi Node; Yoshihiro Urade
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2008-03-16
Journal Detail:
Title:  Atherosclerosis     Volume:  201     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  385-91     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan. inouete@med.saga-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Atherosclerosis / metabolism
Biological Markers / blood*
Coronary Artery Disease / metabolism*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Intramolecular Oxidoreductases / blood*
Lipocalins / blood,  metabolism*
Male
Middle Aged
Prostaglandin D2 / metabolism
ROC Curve
Regression Analysis
Risk Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipocalins; 41598-07-6/Prostaglandin D2; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.99.2/prostaglandin R2 D-isomerase

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